Tıp Fakültesi, Tıbbi Patoloji Anabilim Dalı Koleksiyonu

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https://hdl.handle.net/11616/11756

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Endometrioid tip endometrial karsinomlarda mmp9 ve fascın-1 ekspresyonunun prognostik faktörlerle ilişkisi
(İnönü Üniversitesi, 2017) Tecellioğlu, Fahriye Seçil
Endometrial karsinom kadınlarda dünyada 5. ve Türkiye'de en sık görülen 4. sıradaki kanser olup gelişmiş ülkelerde kadınlarda jinekolojik traktın en sık kanseridir. Endometrial karsinom, endokrin özellikler, morfolojik özellikler ve klinik seyre göre iki alt tipe ayrılarak incelenir; östrojen bağımlı Tip 1 (prototipi endometrioid tip) ve östrojenden bağımsız gelişen Tip 2 (prototipi seröz tip). Endometrioid tipte histolojiye sahip olanlar endometrial karsinomların %80'ini oluşturur. Endometrioid tip tanı anında genellikle evre I, kür şansı yüksek, iyi-orta derece diferansiye kanserlerden oluşur. Genellikle prognozları iyi olmasına rağmen bazı subgruplar için prognoz kötü seyredebilir. Endometrial karsinogenez konusunda moleküler çalışmalar devam etmektedir. Kanserin invaziv potansiyeli ve prognozu hakkında edinilecek bilgi, klinik davranış ve tedaviyi yönlendirmek açısından oldukça önemlidir. Kanserin invazyon mekanizmasında invaziv yüzeyde, çok sayıda mediatörün düzenlediği epitelyal ve stromal etkileşimlerle Epitelyal-Mezenkimal Transizyon(EMT) gündeme gelmiştir. Bu mekanizma kanserin invaziv yüzeyindeki invazyon yapabilme kapasitesi kazanan epitelyal kanser hücrelerinin mezenkimal özellikler kazanmasına dayanmaktadır. Matriks metalloproteinazlar (MMP)ve Fascin-1'in EMT sürecinde rol oynadığı ve tümör invazyonundaki önemini vurgulayan çok sayıda çalışma mevcuttur. Bu çalışmada amacımız, endometrioid tip endometrial karsinomda, karsinogenezin invazyon basamaklarında etkili olduğu düşünülen ve prognozunu etkileyen Fascin-1 ve MMP9 antikorların ekspresyonlarını prognostik parametrelerle ilişkisini araştırmaktır. Çalışmamıza 2011-2017 yılları arasında Endometrioid tip Endometrial karsinom tanısı almış 100 olgu dâhil edilmiştir. Çalışmada tümör çaplarını 2 cm cut off değerine göre gruplandırdığımızda tümör çapı ve lenfovasküler invazyon ile anlamlı ilişki bulunmuştur. Öte taraftan tümör çaplarının ortalamasını prognostik faktörlerle karşılaştırdığımızda FIGO evresi, miyometrial invazyon varlığı, servikal invazyon varlığı, adneksiyal tutulum, lenf nodu metastaz varlığı ile tümör çapı arasında anlamlı ilişki bulunmuştur. 100 olgu içinde Fascin-1 ile boyanma yoğunluğu skoru 5 ve 5'in altında 81, 5'in üstünde 19 olgu mevcuttur. MMP9 ile boyanma yoğunluğu skoru 5 ve 5'in altında 39, 5'in üzerinde 61 olgu mevcuttur. Fascin-1 ve MMP9 ekspresyonları ile histopatolojik ve klinik prognostik parametrelerle istatistiksel anlamlı ilişki saptanmadı.
Resveratrol reduces light and electron microscopic changes in acetaminophen-induced hepatotoxicity in rats: Role of iNOS expression
(Taylor & francıs ınc, 530 walnut street, ste 850, phıladelphıa, pa 19106 usa, 2018) Gül, Mehmet; Çetin, Aslı; Özyalın, Fatma; Türköz, Yusuf; Otlu, Ali
Introduction: Hepatotoxicity is amajor complication of acetaminophen (APAP), a widely used analgesic and antipyretic drug. Resveratrol (RSV) is a naturally occurring diphenol and it has anticancer, antioxidant, and anti-inflammatory properties. Objectives: In this study, the beneficial effects of RSV on APAP-induced hepatotoxicity was investigated in rats. Materials and methods: Group 1: Ethanol, Group 2: Saline, Group 3: RSV (10 mg/kg/ip), Group 4: APAP (1000 mg/kg/ip/single dose), Group 5: APAP+RSV (20 min after administration of APAP). The rats were sacrificed 24 h after administration of APAP. Light and electron microscopic changes were evaluated. Levels of malondialdehyde (MDA) and glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD) activities were determined in liver tissue. Results: Rats of the ethanol, saline, and RSV groups did not present any histopathological alterations. In the APAP group, we observed vascular congestion, necrosis, inflammation, sinusoidal dilatation, and loss of glycogen content. In the APAP+RSV group, these changes were markedly reduced. iNOS immunostaining showed very weak positive stained hepatocytes the sections of control, saline, and RSV groups. However, in the APAP group, iNOS immunostaining was most evident in pericentral hepatocytes. In the same areas in APAP+RSV group, intensity of iNOS immunostaining decreased. A significant increase in MDA and decreases in GSH level, CAT, and SOD activity indicated that APAP-induced hepatotoxicity was mediated through oxidative stress. Significant beneficial changes were noted in tissue oxidative stress indicators in rats treatedwith RSV. Conclusion: These biochemical, histopathological, and ultrastructural findings revealed that RSV reduced the severity of APAP-induced alterations in liver.
A rarely seen pathology "ıntramedullary spinal metastasis"; clinical series of five patients in asingle ınstitution
(Journal of academıc research ın medıcıne-jarem, 2018) Akyuva, Yener; Karadag, Nese; Onal, Cagatay
Objective: Our study is related to our experiences with intramedullary spinal cord metastasis (ISCM). The purpose of the present study was to evaluate the clinical features, treatment, and natural course of patients in the context of the literature. Methods: Five patients with ISCM who were admitted to the neurosurgery department between October 2011 and December 2016 and who underwent surgery were identified. Relevant clinical data were obtained. Results: Of the five patients, three had lung cancer, one had breast cancer, and one had renal cell carcinoma. The presenting symptoms were pain, urinary incontinence, and/or weakness. Tumors were at the thoracic level in three patients, cervical level in one patient, and thoracolumbar level in one patient. One patient with lung cancer had undergone metastasectomy for intracranial metastasis. The pathological examination of one patient had been reported as anaplastic ependymoma in a previous health facility, but breast cancer metastasis was found to be the primary diagnosis following the examination of the material obtained from the excision of the relapsed tumor. Conclusion: The diagnosis of ISCM is difficult, and treatment is usually ineffective. Although there is no exact treatment modality in ISCM, appropriate surgery positively affects morbidity and mortality. Planning the right treatment for the right patient is the most important step of ISCM management.
Is airborne transmission of Acinetobacter baumannii possible A prospective molecular epidemiologic study in a tertiary care hospital
(American Journal of Infection Control, 2016) Yakupoğulları, Yusuf; Otlu, Barış; Ersoy, Yasemin; Kuzucu, Çiğdem; Bayındır, Yaşar; Kayabaş, Üner; Togal, Türkan; Kızılkaya, Canan
Background: Understanding the dynamics of aerial spread of Acinetobacter may provide useful information for production of effective control measurements. We investigated genetic relationships between air and clinical isolates of Acinetobacter baumannii in an intensive care unit (ICU) setting. Methods: We conducted a prospective surveillance study in a tertiary care hospital for 8 months. A total of 186 air samples were taken from 2 ICUs. Clonal characteristics of air isolates were compared with the prospective clinical strains and the previously isolated strains of ICU patients over a 23-month period. Results: Twenty-six (11.4%) air samples yielded A baumannii, of which 24 (92.3%) isolates were carbapenemresistant. The Acinetobacter concentration was the highest in bedside sampling areas of infected patients (0.39 CFU/ m3). Air isolates were clustered in 13 genotypes, and 7 genotypes (including 18 air strains) were clonally related to the clinical strains of 9 ICU patients. One clone continued to be cultured over 27 days in ICU air, and air isolates could be clonally related to 7-week retrospective and approximately 15-week prospective clinical strains. Conclusions: The results of this study suggest that infected patients could spread significant amounts of Acinetobacter to ICU air. These strains could survive in air for some weeks and could likely still infect new patients after some months. Special control measurements may be required against the airborne spread of Acinetobacter in ICUs.

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