Tıp Fakültesi, Beyin ve Sinir Cerrahisi Anabilim Dalı Koleksiyonu
Bu koleksiyon için kalıcı URI
Güncel Gönderiler
Öğe Neuroprotection against ccl4 induced brain damage with crocin in wistar rats(Bıotechnıc & hıstochemıstry, 2018) Altinoz, E; Erdemli, ME; Gül, M.; Aksungur, Z; Gül, S; Çanta, HG; Kaya, GB; Turkoz, YOwing to its lipophilic property, carbon tetrachloride (CCl4) is rapidly absorbed by both the liver and brain. We investigated the protective effects of crocin against brain damage caused by CCl4. Fifty rats were divided into five groups of ten: control, corn oil, crocin, CCl4 and CCl4 + crocin. CCl4 administration decreased glutathione (GSH) and total antioxidant status (TAS) levels, and catalase (CAT) activity, while significant increases were observed in malondialdehyde (MDA) and total oxidant status (TOS) levels and superoxide dismutase (SOD) activity. The cerebral cortex nuclear lamina developed a spongy appearance, neuronal degeneration was observed in the hippocampus, and heterochromatic and pyknotic neurons with increased cytoplasmic eosinophilia were observed in the hippocampus after CCl4 treatment. Because crocin exhibits strong antioxidant properties, crocin treatment increased GSH and TAS levels and CAT activities, and decreased MDA and TOS levels and SOD activity; significant improvements also were observed in histologic architecture. We found that crocin administration nearly eliminated CCl4 induced brain damage by preventing oxidative stress.Öğe Anterior fontanel dermoid kistleri(Atatürk Üniv Tıp Bül, 1980) Behiç,Tümer; Aydın, İsmail Hakkı; Önder, ArifÖğe Lumbar disk hernilerinin tanısında lumbar epidural venografi(Atatürk Üniv. Tıp Bül., 1985) Aydın, İsmail Hakkı; Önder, Arif; Tümer, Behiç; Aladağ, Mehmet Arif; Güney, Şefik; Aydın, YusufÖğe Antiepileptik ilaç alan ve almayan epilepsili olgularda serum ve BOS bakır ve çinko düzeyleri(Atatürk Üniv. Tıp Bül., 1987) İskender, Kocaman; Yılıkoğlu, Yalçın; Parlak, Ömer; İyigün, İbrahim; Değer, Orhan; Aydın, İsmail Hakkı; Önder, ArifÖğe Arteria karotis interna fibromuskuler displazisi(Atatürk Üniv. Tıp Bül., 1988) Aydın, İsmail Hakkı; Yılıkoğlu, Yalçın; İyigün, İbrahim; Önder, Arif; Narin, MehmetÖğe Servikal travmaların tedavisinde cloward operasyonunun yeri(Atatürk Üniv. Tıp Bül., 1988) Önder, Arif; Ak, Hüseyin Erdem; Kadıoğlu, Hakan Hadi; Takçı, Erhan; Aydın, İsmail HakkıÖğe Ekstradural hematomlar 179 olgunun klinik analizi(Atatürk Üniv. Tıp Bül., 1988) Önder, Arif; Kadıoğlu, Hakan Hadi; Kayaoğlu, Çetin Refik; Aydın, İsmail HakkıÖğe Çocuklarda ağır kafa travmalarının prognozu(Atatürk Üniv. Tıp Bül., 1988) Aydın, İsmail Hakkı; Kadıoğlu, Hakan Hadi; Kayaoğlu, Çetin Refik; Önder, Arif; Gezen, Ahmet FerruhÖğe Clinical analysis of cerebral abscesses(Zent Bl Neurochir, 1988) Aydın, İsmail Hakkı; Aladağ, Mehmet Arif; Kadıoğlu, Hakan Hadi; Önder, Arif42 patients with cerebral abscesses were treated from 1979 until the end of the first six months of 1987 at the Neurosurgical Department of the Faculty of Medicine, Atatürk University, Erzurum, Turkey. The present study aims at studying these patients to determine the factors affecting on prognosis. The patients were studied for the duration of complaints, pre-operational condition, the location of the abscesses, the microorganisms responsible for them, and the techniques of operation applied, by taking their sex and age into consideration. All of the cases were treated operatively. Of these, 18 were treated by excision and 24 were applied drainage, whose percentage was 43 and 57 respectively, 85% of the cases were under 60 years of age. The rate of mortality of the cases with cerebral abscesses was 19%. This rate was between 15% and 37.5% in the cases of several age groups whose complaints lasted less than two months. This rate reached 100% with a sudden increase in the cases who had a duration of complaints over four months. The rate of mortality was 6.2% in the cases with a clear conscious and cooperative ability while it had a significant increase in the patients in pre-coma or coma to go up to 50% and 75% respectively. No correlation was observed between the rate of mortality and the age of the patients but the location and extension of the abscesses had an effect on this rate. The abscesses, covering more than one lobe, had a mortality rate of 31.2%, while the ones with parietal location caused no single death. To conclude, we can say, based on this study, that the age and sex of patients and the operative technique have no effect on the rate of mortality while it is obviously influenced by the duration of the complaints and the pre-operative condition. Consequently, we would like to stress up on early diagnosis and treatment of such cases.Öğe Vertebral kist hidatikler(Atatürk Üniv Tıp Bül, 1990) Önder, Arif; Aydın, İsmail Hakkı; Ak, Hüseyin Erdem; Takçı, ErhanÖğe Disseminated intravascular coagulation and cranial trauma(Atatürk Üniv. Tıp Bül., 1990) Yolaş, Coşkun; Önder, Arif; Aydın, İsmail HakkıÖğe Akut subdural hematomlar klinik analiz(Atatürk Üniv. Tıp Bül., 1991) Kadıoğlu, Hakan Hadi; Önder, Arif; Takçı, Erhan; Kayaoğlu, Çetin Refik; Aydın, İsmail HakkıÖğe Maksillo fasyal travmalar klinik analiz(Atatürk Üniv. Tıp Bül., 1991) Kadıoğlu, Hakan Hadi; Önder, Arif; Aydın, İsmail Hakkı; Tüzün, Şenol; Takçı, ErhanÖğe Kranio serebral erozyon(Atatürk Üniv. Tıp Bül., 1991) Önder, Arif; Aydın, İsmail Hakkı; Takçı, Erhan; Kayaoğlu, Çetin RefikÖğe The effect of very early cisternal irrigation on basilar artery spasm after SAH In the rat model(Acta Neurochir, 1991) Aydın, İsmail Hakkı; Önder, ArifThe authors have investigated the effect of very early irrigation of the cerebrospinal fluid (CSF) space in the haemorrhage rat model of vasospasm. Fifteen rats had basilar cistern irrigation with physiological saline for 3 hours after subarachnoid haemorrhage (SAH), and fifteen control rats had subarachnoid haemorrhage without irrigation of clot. The changes in basilar arteries diameters were determined by angiograms obtained from the rats. The post haemorrhage anglograms showed significant basilar artery spasm in both groups (P ~< 0.0005, t-test). However in the last angiogram the basilar artery diameter was found to have the same value measured before subarachnoid haemorrhage in the irrigation group whereas no obvious change was observed in the control group. In the irrigation group the mean diameter of the basilar artery in the last angiogram was 0.412ram. (0.30ram to 0.50mm). None of the animals, treated by cisternal irrigation, showed angiographic vasospasm while the latter group did (P ~< 0.0005). Animals treated with physiological saline irrigation had a median clot grade of 0.40 (range grade 0 to 2); control rats had a median grade 2.86 (range grade 1 to 4, P < 0.001, Mann-Withney U test), on the brain stem, indicating significant reduction of clot by lavage. In conclusion, performance of experimental physiological saline irrigation at a very early time after subarachnoid haemorrhage prevents the arteriographic and morphological changes of both acute and late vasospasms.Öğe Vertebral arteriovenous fistula(Vascular Surgery, 1991) Koçak, Hikmet; Paç, Mustafa; Ateşal, Sebahattin; Yekeler, İbrahim; Önder, ArifÖğe The role of combined therapy in supratentorial astrocytomas(Atatürk Üniv. Tıp Bül., 1992) Önder, Arif; Takçı, Erhan; Kadıoğlu, Hakan Hadi; Tahmazoğlu,İbrahim; İyigün, İbrahim; Aydın, İsmail HakkıÖğe Nöral tüp defektlerinin AFP ve ultrasonografi yardımı İle intrauterin tesbiti multidisipliner çalışma(Hipokrat, 1992) Parlak, Ömer; Önder, Arif; Hacıyakupoğlu, Sebahattin; Okur, Adnan; Aydın , İsmail HakkıÖğe Sıçanlarda deneysel subaraknoid kanama sonrası baziler arter duvarında meydana gelen ultrastrüktürel değişiklikler(Nörolo. Bil. D., 1992) Önder, Arif; Kayaoğlu, Çetin Refik; Kadıoğlu, Hakan Hadi; Aydın, İsmail HakkıÖğe Deneysel intraserebral hematomlarda ürokinazın etkisi(Hipokrat, 1992) Takçı, Erhan; Önder, Arif; Kadıoğlu, Hakan Hadi; Aydın, İsmail Hakkı
