Thymoquinone is protective against 2,3,7,8-tetrachlorodibenzo-p-dioxininduced hepatotoxicity

Basit Öğe Kaydı
dc.contributor.authorErdemli, ME
dc.contributor.authorYigitcan, B.
dc.contributor.authorGül, M.
dc.contributor.authorÇanta, HG
dc.contributor.authorGül, S.
dc.contributor.authorAksungur, Z.
dc.date.accessioned2019-07-23T12:41:19Z
dc.date.available2019-07-23T12:41:19Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe investigated changes in rat liver tissues following administration of thymoquinone (TQ) against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced hepatotoxicity. Fifty rats were assigned randomly to five groups of 10 as follows: control, corn oil, TCDD, TQ and TCDD + TQ. Biochemical and histopathological analyses were conducted on liver tissue. We found that 30 day TCDD administration caused histopathological changes in liver including thickening of Glisson's capsule, intracytoplasmic vacuolization in hepatocytes, sinusoidal dilation, vascular and sinusoidal congestion and inflammatory cell infiltration. TCDD administration increased malondialdehyde (MDA), total oxidant status (TOS), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels in rat liver tissue and reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and total antioxidant status (TAS) levels compared to all other groups. In the TQ treated group, GSH, SOD, CAT and TAS levels increased compared to all other groups. MDA, TOS, ALT, AST, ALP levels decreased compared to all other groups. Our histological findings were consistent with the biochemical findings. The oxidative and histologic effects of TCDD were eliminated by TQ treatment. TCDD administration caused oxidative stress in rat liver and TQ administered with TCDD prevented TCDD induced hepatotoxicity. TQ could be considered an alternative anti-TCDD toxicity agent.en_US
dc.identifier.citationErdemli, ME. Yigitcan, B. Gul, M. Bag, HG. Gul, S. Aksungur, Z . (2018). Thymoquinone is protective against 2,3,7,8-tetrachlorodibenzo-p-dioxininduced hepatotoxicity. Cilt:93. Sayı:6. 453-462 ss.en_US
dc.identifier.doi10.1080/10520295.2018.1453549en_US
dc.identifier.endpage462en_US
dc.identifier.issue6en_US
dc.identifier.startpage453en_US
dc.identifier.urihttps://hdl.handle.net/11616/12874
dc.identifier.volume93en_US
dc.language.isoenen_US
dc.publisherTaylor & francıs ltd, 2-4 park kare, mılton park, abıngdon or14 4rn, oxon, ingiltereen_US
dc.relation.ispartofBıotechnıc & hıstochemıstryen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPolychlorınated-bıphenyls pcbsen_US
dc.subjecttotal antıoxıdant capacıtyen_US
dc.subjectoxıdatıve stressen_US
dc.subjectdna-damageen_US
dc.subjectlıver-ınjuryen_US
dc.subjectrat-lıveren_US
dc.subjectvıtamın-een_US
dc.subjecttcdden_US
dc.subjectapoptosısen_US
dc.subjectexercıseen_US
dc.titleThymoquinone is protective against 2,3,7,8-tetrachlorodibenzo-p-dioxininduced hepatotoxicityen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
makale.pdf
Boyut:
2.23 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.71 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı Koleksiyonu