Could ferritin, vitamin B12, and vitamin D play a role in the etiopathogenesis of fibromyalgia syndrome?

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dc.authoridAydogan Baykara, Rabia/0000-0003-0542-266X
dc.authoridCure, Medine Cumhur/0000-0001-9253-6459
dc.authoridCüre, Erkan/0000-0001-7807-135X
dc.authorwosidAydogan Baykara, Rabia/ACI-5046-2022
dc.authorwosidCure, Medine Cumhur/A-1089-2018
dc.authorwosidCüre, Erkan/W-4922-2017
dc.contributor.authorKucuk, Adem
dc.contributor.authorBaykara, Rabia Aydogan
dc.contributor.authorTuzcu, Ayca
dc.contributor.authorOmma, Ahmet
dc.contributor.authorCure, Medine Cumhur
dc.contributor.authorCure, Erkan
dc.contributor.authorAcet, Gunseli Karaca
dc.date.accessioned2024-08-04T20:57:33Z
dc.date.available2024-08-04T20:57:33Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction. Fibromyalgia syndrome (FS) comprises general body pain, sleep disturbances, and fatigue. Vitamin B-12 (VB), vitamin D (VD), and iron deficiencies lead to similar complaints. First, this study aimed to evaluate the VB, VD, and ferritin levels of patients with FS. Second, it aimed to investigate whether there was a relationship between these parameters and FS severity. Material and methods. The study included 58 female patients with FS and 58 healthy females as a control group. The patients completed the Fibromyalgia Impact Questionnaire (FIQ), Visual Analog Scale (VAS), fatigue questionnaire, Pittsburgh sleep quality scale, and the Short Form36 (SF-36). This study examined the VD, VB, and ferritin levels of the patient and control groups. Results. The VB (240.0 [110.0-394.0] vs 291.0 [210.0-609.0] pg/ml, p<0.001), VD (12.5 [3.0-45.0] vs 20.0 [5.0-54.0] ng/ml, p=0.013), and ferritin levels (21.2 [4.0-86.0] vs 32.0 [7.1-120.0], ng/ml, p=0.009) of the FS patients were determined to be significantly lower than those of the control group. A negative correlation was determined between the number of tender points and VB, VD, and ferritin levels. In the regression analysis, we found low ferritin levels (odds ratio [OR] 1.036, 95% confidence interval [CI] 1.015-1.058, p<0.001) and VB (OR 1.010, CI 1.002-1.018, p=0.010) to be an independent risk factor for FS. Conclusions. There may be a relationship between VB, VD, and ferritin levels and the number of tender points in patients with FS. Levels of iron and VB may play a vital role in FS etiopathogenesis. However, VD levels may not be a risk factor for FS etiopathogenesis.en_US
dc.identifier.doi10.2478/rjim-2021-0022
dc.identifier.endpage393en_US
dc.identifier.issn1582-3296
dc.identifier.issn2501-062X
dc.identifier.issue4en_US
dc.identifier.pmid34142515en_US
dc.identifier.startpage384en_US
dc.identifier.urihttps://doi.org/10.2478/rjim-2021-0022
dc.identifier.urihttps://hdl.handle.net/11616/102718
dc.identifier.volume59en_US
dc.identifier.wosWOS:000726787900008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSciendoen_US
dc.relation.ispartofRomanian Journal of Internal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectfibromyalgiaen_US
dc.subjectvitamin B-12en_US
dc.subjectvitamin Den_US
dc.subjectironen_US
dc.subjectanemiaen_US
dc.titleCould ferritin, vitamin B12, and vitamin D play a role in the etiopathogenesis of fibromyalgia syndrome?en_US
dc.typeArticleen_US

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