Association of single nucleotide polymorphisms in CXCR1, CXCR2 and CXCL5 with Behcet disease: a study in the Denizli province of Turkey

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dc.authoridOZTURK, Onur/0000-0003-3404-4135
dc.authoridArikan, Sanem/0000-0001-7987-9078
dc.authorwosidArıkan, Sanem/ABI-6170-2020
dc.authorwosidATALAY, AYFER/HKO-1963-2023
dc.authorwosidDuygulu, Şeniz/HIR-2895-2022
dc.authorwosidOZTURK, Onur/HLH-4990-2023
dc.contributor.authorArikan, S.
dc.contributor.authorAtalay, A.
dc.contributor.authorOzturk, O.
dc.contributor.authorDuygulu, S.
dc.contributor.authorAtalay, E. O.
dc.date.accessioned2024-08-04T20:57:12Z
dc.date.available2024-08-04T20:57:12Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground Behcet disease (BD) is associated with the immune system, especially neutrophilic activity. The CXCR1, CXCR2 and CXCL5 genes mediate the activation and migration of neutrophils. Aim To investigate CXCR1, CXCR2 and CXCL5 single nucleotide polymorphisms (SNPs) and examine their association with BD. Methods We studied polymorphic sites in CXCR1 (four sites: rs16858811, rs9282752, rs16858809 and rs16858808), CXCR2 (three sites: rs2230054, rs1126579 and rs1126580) and CXCL5 (one site: rs352046) in 87 patients with BD and 111 healthy controls (HCs), using a PCR restriction-fragment length polymorphism-based approach for genotyping. Results We found that the CXCR2 rs2230054 TT genotype and the CXCL5 rs352046 polymorphism might be possible genetic factors responsible for BD. We did not find any association between the development of BD and any of the four CXCR1 polymorphisms or the other two CXCR2 SNPs. In addition, our haplotype analysis results indicated that the haplotypes of the CXCR2 and CXCR1-CXCR2 polymorphic loci were different between the BD and HC groups. Conclusion Our study suggests that polymorphisms of CXCR1, CXCR2 and CXCL5 may affect susceptibility to BD and increase the risk of developing the disease. These loci need to be studied in larger groups of patients from different geographical areas around the world in order to clarify the genetic background for BD pathogenesis.en_US
dc.description.sponsorshipTUBITAK [SBAG-2388, 113S163]; Pamukkale University Research Fund [2001TPF020]en_US
dc.description.sponsorshipThis study was supported under the framework of the TUBITAK (project nos SBAG-2388, 113S163) and Pamukkale University Research Fund (project no. 2001TPF020).en_US
dc.identifier.doi10.1111/ced.14766
dc.identifier.endpage1470en_US
dc.identifier.issn0307-6938
dc.identifier.issn1365-2230
dc.identifier.issue8en_US
dc.identifier.pmid34050991en_US
dc.identifier.startpage1462en_US
dc.identifier.urihttps://doi.org/10.1111/ced.14766
dc.identifier.urihttps://hdl.handle.net/11616/102432
dc.identifier.volume46en_US
dc.identifier.wosWOS:000684283700001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical and Experimental Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPopulation-Geneticsen_US
dc.subjectIl-8 Geneen_US
dc.subjectConversionen_US
dc.subjectChemokineen_US
dc.subjectSclerosisen_US
dc.subjectRisken_US
dc.titleAssociation of single nucleotide polymorphisms in CXCR1, CXCR2 and CXCL5 with Behcet disease: a study in the Denizli province of Turkeyen_US
dc.typeArticleen_US

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