Correlation of clinical, endoscopic, and histological findings with virulence factors in children with Helicobacter pylori gastritis

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dc.authorid101949en_US
dc.contributor.authorSelimoğlu, Mukadder A.
dc.contributor.authorKarabiber, Hamza
dc.contributor.authorOtlu, Barış
dc.contributor.authorYıldırım, Özge
dc.contributor.authorÖzer, Ali
dc.contributor.authorŞamdancı, Emine
dc.date.accessioned2017-07-14T06:53:59Z
dc.date.available2017-07-14T06:53:59Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and goals: As there are limited data regarding the correlation between virulence factors and clinical, endoscopic, and histological findings in children with Helicobacter pylori gastritis, we aimed to evaluate that probable relationship in pediatric cases. Study: One hundred and fifty-nine children with chronic abdominal pain or dyspepsia were included in this study. Upper gastrointestinal endoscopy was performed and multiple biopsy samples were taken from the esophagus, the antrum, and the duodenum. PCR was used for the determination of virulence factors. Results: According to PCR analysis, 98 (61.6%) children were positive for H. pylori. Using histopathological examination and culture, H. pylori was detected in 65 (40.9%) and 51 (32.1%) children, respectively. Peptic ulcer prevalence and histopathological features were not different among cagA, cagE, or iceA1 positive and negative groups (P>0.05). Peptic ulcer prevalence and histopathological findings were more common in iceA2-positive patients (P<0.05). Antral nodularity was more common in cagA-positive patients (P<0.05). Endoscopic and histological features were not different among patients with or without m1 or m2 strains (P>0.05). S1b positivity was associated with a higher esophagitis rate (P<0.05). Conclusion: Among virulence factors, iceA2 was associated with peptic ulcer and milder histopathological findings, and vacAs1 was associated with milder histopathological findings.en_US
dc.identifier.citationSelimoğlu, M. A. Karabiber, H. Otlu, B. Yıldırım, Ö. Özer, A. Şamdancı, E. (2014). Correlation of clinical endoscopic and histological findings with virulence factors in children with Helicobacter pylori gastritis. European Journal of Gastroenterology & Hepatology, 26 (6); 602-606.en_US
dc.identifier.doi10.1097/MEG.0000000000000095en_US
dc.identifier.endpage606en_US
dc.identifier.issn0954-691X
dc.identifier.issue6en_US
dc.identifier.startpage602en_US
dc.identifier.urihttp://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00042737-900000000-98896
dc.identifier.urihttps://hdl.handle.net/11616/7369
dc.identifier.volume26en_US
dc.language.isoenen_US
dc.publisherEuropean Journal of Gastroenterology & Hepatologyen_US
dc.relation.ispartofEuropean Journal of Gastroenterology & Hepatologyen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.titleCorrelation of clinical, endoscopic, and histological findings with virulence factors in children with Helicobacter pylori gastritisen_US
dc.typeArticleen_US

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