The effect of atorvastatin and its role on systemic cytokine network in treatment of acute experimental colitis

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dc.authorid41809en_US
dc.contributor.authorAktunç, Erol
dc.contributor.authorKayhan, Başak
dc.contributor.authorAraslı, Mehmet
dc.contributor.authorDoğan Gün, Banu
dc.contributor.authorBarut, Figen
dc.date.accessioned2017-08-01T11:00:24Z
dc.date.available2017-08-01T11:00:24Z
dc.date.issued2011
dc.departmentİnönü Üniversitesien_US
dc.description.abstractInflammatory bowel diseases are characterized by disabilities in gastrointestinal system and defects in mucosal immune system. Statins are 3-hydroxy-3-methyl glutaryl coenzyme A reductase inhibitor and are used to treat hypercholesterolemia in patients with coronary artery and atherosclerotic diseases. Recent studies have demonstrated that statins have immunomodulatory role by effecting different pathways in immune system. In this study, we investigated the effect of atorvastatin and its mechanism on systemic immune response in treatment of trinitrobenzene sulfonic acid (TNBS)-induced colitis mice. We observed that atorvastatin significantly suppressed the severity of TNBS-induced colitis in BALB/c mice. This was manifested in reduced rectal bleeding, decrease in colon length, reduction of histological damage, and improved survival. Concurrently, we investigated the immunomodulatory role of atorvastatin on systemic immune system. We investigated the proinflammatory (IL-1α, IL-6, TNF-α), Th1 (IFN-γ, IL-2), Th2 (IL-4, IL-5, IL-10), and Th17 (IL-17, IL-23) cytokine levels in serum samples of colitis and atorvastatin-administered mice. We discovered that administration of atorvastatin significantly down-regulates systemic TNF-α level and Th17 cytokine levels. Furthermore, atorvastatin treatment switches Th1 type T-cell response toward/to Th2 (IL-4, IL-10) type response.en_US
dc.identifier.citationAktunç, E. Kayhan, B. Araslı, M. Doğan Gün, B. Barut, F. (2011). The effect of atorvastatin and its role on systemic cytokine network in treatment of acute experimental colitis. Immunopharmacology and Immunotoxicology, 33(4), 667–675.en_US
dc.identifier.doi10.3109/08923973.2011.559475en_US
dc.identifier.endpage675en_US
dc.identifier.issn0892-3973
dc.identifier.issue4en_US
dc.identifier.startpage667en_US
dc.identifier.urihttp://www.tandfonline.com/doi/full/10.3109/08923973.2011.559475
dc.identifier.urihttps://hdl.handle.net/11616/7432
dc.identifier.volume33en_US
dc.language.isoenen_US
dc.publisherImmunopharmacology and Immunotoxicologyen_US
dc.relation.ispartofImmunopharmacology and Immunotoxicologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInflammatory bowel diseasesen_US
dc.subjectStatinen_US
dc.subjectSystemic immune responseen_US
dc.subjectTh1en_US
dc.subjectTh2en_US
dc.subjectTh17en_US
dc.subjectCytokinesen_US
dc.titleThe effect of atorvastatin and its role on systemic cytokine network in treatment of acute experimental colitisen_US
dc.typeArticleen_US

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