Evaluation of in vivo cerebral metabolism on proton magnetic resonance spectroscopy in patients with impaired glucose tolerance and type 2 diabetes mellitus

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dc.authoridSahin, Ibrahim/0000-0002-6231-0034
dc.authoridSigirci, Ahmet/0000-0001-9221-0002
dc.authoridKarakas, Hakki/0000-0002-1328-8520
dc.authorwosidSahin, Ibrahim/ABI-6050-2020
dc.authorwosidŞahin, İbrahim/HHY-8303-2022
dc.authorwosidSigirci, Ahmet/ABG-7387-2020
dc.contributor.authorSahin, Ibrahim
dc.contributor.authorAlkan, Alpay
dc.contributor.authorKeskin, Lezzan
dc.contributor.authorCikim, Ayse
dc.contributor.authorKarakas, Hakki M.
dc.contributor.authorFirat, Ahmet K.
dc.contributor.authorSigirci, Ahmet
dc.date.accessioned2024-08-04T20:58:44Z
dc.date.available2024-08-04T20:58:44Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate possible metabolic alterations in cerebral tissues on magnetic resonance spectroscopy (MRS) in patients with impaired glucose tolerance (IGT) and with type 2 diabetes mellitus (T2-DM). Twenty-five patients with T2-DM, 13 patients with IGT, and 14 healthy volunteers were included. Single-voxel spectroscopy (TR: 2000 ms, TE: 31 ms) was performed in all subjects. Voxels were placed in the frontal cortex, thalamus, and parietal white matter. N-acetylaspartate (NAA)/creatine (Cr), choline (Cho)/Cr, and myo-inositol (MI)/Cr ratios were calculated. Frontal cortical Cho/Cr ratios were increased in patients with IGT compared to control subjects. Parietal white matter Cho/Cr ratios were significantly higher in patients with IGT when compared to patients with T2-DM. In the diabetic group, frontal cortical MI/Cr ratios were increased, and parietal white matter Cho/Cr ratios were decreased when compared to the control group. Frontal cortical NAA/Cr and Cho/Cr ratios and parietal white matter Cho/Cr ratios were decreased in diabetic patients with poor glycemic control (AlC>10%). AlC levels were inversely correlated with frontal cortical NAA/Cr and Cho/Cr ratios and with parietal white matter Cho/Cr ratios. T2-DM and IGT may cause subtle cerebral metabolic changes, and these changes may be shown with MRS. Increased Cho/Cr ratios may suggest dynamic change in membrane turnover in patients with IGT. Diabetic patients with poor glycemic control may be associated with neuronal dysfunction/damage in brain in accordance with AlC levels and, in some, extend with insulin resistance. (C) 2008 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jdiacomp.2007.03.007
dc.identifier.endpage260en_US
dc.identifier.issn1056-8727
dc.identifier.issue4en_US
dc.identifier.pmid18413166en_US
dc.identifier.startpage254en_US
dc.identifier.urihttps://doi.org/10.1016/j.jdiacomp.2007.03.007
dc.identifier.urihttps://hdl.handle.net/11616/103115
dc.identifier.volume22en_US
dc.identifier.wosWOS:000257868200005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal of Diabetes and Its Complicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdiabetesen_US
dc.subjectimpaired glucose toleranceen_US
dc.subjectmagnetic resonance spectroscopyen_US
dc.subjectbrainen_US
dc.titleEvaluation of in vivo cerebral metabolism on proton magnetic resonance spectroscopy in patients with impaired glucose tolerance and type 2 diabetes mellitusen_US
dc.typeArticleen_US

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