Does intraperitoneal medical ozone preconditioning and treatment ameliorate the methotrexate induced nephrotoxicity in rats?

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dc.authoridPOLAT, Cemal/0000-0002-1587-3934
dc.authoridsoyer, haci vural/0000-0003-4271-7467
dc.authoridCelik (Erdogan), Betul/0000-0001-9731-9939
dc.authoridCakir, Tugrul/0000-0001-7952-8462
dc.authorwosidPOLAT, Cemal/ADL-8092-2022
dc.authorwosidÇakır, Tuğrul/AAD-1906-2019
dc.authorwosidsoyer, haci vural/KAM-0073-2024
dc.authorwosidPolat, Cemal/AAX-9226-2020
dc.authorwosidBasturk, Ahmet/V-9914-2017
dc.authorwosidAkyüz, Cebrail/AGY-4201-2022
dc.authorwosidCelik (Erdogan), Betul/AAD-1815-2019
dc.contributor.authorAslaner, Arif
dc.contributor.authorCakir, Tugrul
dc.contributor.authorCelik, Betul
dc.contributor.authorDogan, Ugur
dc.contributor.authorMayir, Burhan
dc.contributor.authorAkyuz, Cebrail
dc.contributor.authorPolat, Cemal
dc.date.accessioned2024-08-04T20:57:42Z
dc.date.available2024-08-04T20:57:42Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractMethotrexate is a chemotherapeutic agent used for many cancer treatments. It leads to toxicity with its oxidative injury. The purpose of our study is investigating the medical ozone preconditioning and treatment has any effect on the methotrexate-induced kidneys by activating antioxidant enzymes in rats. Eighteen rats were divided into three equal groups; control, Mtx without and with medical ozone. Nephrotoxicity was performed with a single dose of 20 mg/kg Mtx intraperitoneally at the fifteenth day of experiment on groups 2 and 3. Medical ozone preconditioning was performed at a dose of 25 mcg/ml (5 ml) intraperitoneally everyday in the group 3 and treated with medical ozone for five more days while group 2 was received only 5 ml of saline everyday for twenty days. All rats were sacrificed at the end of third week and the blood and kidney tissue samples were obtained to measure the levels of TNF-alpha, IL-1 beta, malondialdehyde, glutathione and myeloperoxidase. Kidney injury score was evaluated histolopatologically. Medical ozone preconditioning and treatment ameliorated the biochemical parameters and kidney injury induced by Mtx. There was significant increase in tissue MDA, MPO activity, TNF-alpha and IL-1 beta (P<0.05) and significant decrease in tissue GSH and histopathology (P<0.05) after Mtx administration. The preconditioning and treatment with medical ozone ameliorated the nephrotoxicity induced by Mtx in rats by activating antioxidant enzymes and prevented renal tissue.en_US
dc.identifier.endpage13817en_US
dc.identifier.issn1940-5901
dc.identifier.issue8en_US
dc.identifier.pmid26550330en_US
dc.identifier.startpage13811en_US
dc.identifier.urihttps://hdl.handle.net/11616/102859
dc.identifier.volume8en_US
dc.identifier.wosWOS:000365271900232en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKidneyen_US
dc.subjectmedical ozoneen_US
dc.subjectpreconditioningen_US
dc.subjectmethotrexateen_US
dc.subjectnephrotoxicityen_US
dc.titleDoes intraperitoneal medical ozone preconditioning and treatment ameliorate the methotrexate induced nephrotoxicity in rats?en_US
dc.typeArticleen_US

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