Effects of valproate and carbamazepine on serum levels of homocysteine vitamin B12 and folic acid

Basit Öğe Kaydı
dc.authorid101949en_US
dc.contributor.authorKarabiber, Hamza
dc.contributor.authorSönmez, Ergün
dc.contributor.authorÖzerol, Elif
dc.contributor.authorYakıncı, Mehmet Cengiz
dc.contributor.authorOtlu, Barış
dc.contributor.authorYoloğlu, Saim
dc.date.accessioned2017-07-31T13:06:17Z
dc.date.available2017-07-31T13:06:17Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHomocysteine (HMC) is a sulfur containing amino acid, which plays a role in methionine metabolism. Folic acid (FA) and vitamin B12 (B12) are essential for remethylization of HMC to methionine. HMC level increases in the deficiency of these vitamins. Hyperhomocysteinemia causes vascular endothelial damage, which causes atherosclerosis. The aim of this study is to investigate the effect of valproate (VA) and carbamazepine (CBZ) on the serum levels of HMC, B12, and FA. Thirty-six children receiving CBZ and 30 children receiving VA for epilepsy for the last 1-year period and 29 healthy children as control were the population of this study. After 6 h of fasting serum HMC, B12, and FA levels were measured and results were compared statistically. Mean values of HMC, FA, and B12 levels in control group were 9.2 ^ 2.7 mmol/l, 9.0 ^ 2.0 ng/ml, and 342 ^ 162 pg/ml, in VA group 14.0 ^ 6.8 mmol/l, 7.3 ^ 2.9 ng/ml, and 368 ^ 159 pg/ml, in CBZ group 16.0 ^ 13.1 mmol/l, 7.5 ^ 3.3 ng/ml, and 285 ^ 158 pg/ml, respectively. Serum HMC levels were higher in VA and CBZ groups than control group (P , 0:01 and P , 0:05, respectively). Serum FA levels were lower in VA and CBZ groups compared to control group (P , 0:05). Serum levels of B12 were not different between VA and control groups (P . 0:05). In CBZ group serum B12 levels were lower than control group (P , 0:05). FA may be added to the treatment protocol (if the patients take only CBZ, then B12 should also be added) for patients taking these antiepileptic drugs to decrease the degenerative effect of VA and CBZ on vascular endothelium.en_US
dc.identifier.citationKarabiber, H. Sönmez, E. Özerol, E. Yakıncı, M. C. Otlu, B. Yoloğlu, S. (2003). Effects of valproate and carbamazepine on serum levels of homocysteine vitamin B12 and folic acid. Brain and Development, 25(2), 113–115.en_US
dc.identifier.doi10.1016/S0387-7604(02)00163-8en_US
dc.identifier.endpage115en_US
dc.identifier.issn03877604
dc.identifier.issue2en_US
dc.identifier.startpage113en_US
dc.identifier.urihttp://linkinghub.elsevier.com/retrieve/pii/S0387760402001638
dc.identifier.urihttps://hdl.handle.net/11616/7415
dc.identifier.volume25en_US
dc.language.isoenen_US
dc.publisherBrain and Developmenten_US
dc.relation.ispartofBrain and Developmenten_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHomocysteineen_US
dc.subjectSodium valproateen_US
dc.subjectCarbamazepineen_US
dc.subjectFolic aciden_US
dc.subjectVitamin B12en_US
dc.titleEffects of valproate and carbamazepine on serum levels of homocysteine vitamin B12 and folic aciden_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Makale Dosyası.pdf
Boyut:
82.84 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.71 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı Koleksiyonu