Prevalence of Pericentric Inversion of Chromosome 9 in Eastern Anatolia Region and Relationship to Reproductive Efficiency

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dc.authoridKorkmaz Sezer, Selcen/0000-0001-9479-3176
dc.authorwosidKorkmaz Sezer, Selcen/ABU-1678-2022
dc.contributor.authorYuksel, Sengul
dc.contributor.authorSavaci, Serap
dc.contributor.authorEkici, Cemal
dc.contributor.authorKurtoglu, Elcin Latife
dc.contributor.authorKorkmaz, Selcen
dc.contributor.authorYesilada, Elif
dc.date.accessioned2024-08-04T21:00:54Z
dc.date.available2024-08-04T21:00:54Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: One of the most common, structurally balanced chromosome rearrangements is the pericentric inversion of chromosome (inv[9]). It is considered to be a variant of the normal karyotype, and has been found in both normal populations and patients with various abnormal phenotypes. The aim of this study was to determine the frequency of chromosome 9 rearrangement in the Malatya Province and check whether it is correlated with certain diseases. Methods: In this study, we investigated the karyotype analysis of 4168 patients admitted in the Turgut Ozal Medical Center and Research Hospital, Genetic Disease Diagnosis Center Laboratory, between 2014 and 2016 and retrospectively reviewed their clinical data. Chromosomes from cultured peripheral blood lymphocytes were analyzed using Giemsa Trypsin-Giemsa (GTG) banding. Results: Pericentric inversion was detected in 71 (1.7 %) of 4168 cases, including 32 (45.1%) cases with inv(9) causing infertilty, 21 (29.6%) causing growth retardation, four (5.6%) causing multiple spontaneous abortion, and 14 (19.7%) causing other abnormalities, all of which were referred to our laboratory. Conclusion: In this study, the distribution of inv (9) in the Malatya Province was shown, and it is believed that these results would contribute to the knowledge regarding the incidence of inv (9) in the Eastern Anatolia Region and Turkey.en_US
dc.identifier.doi10.14744/ejmo.2017.06978
dc.identifier.endpage42en_US
dc.identifier.issn2587-196X
dc.identifier.issue1en_US
dc.identifier.startpage40en_US
dc.identifier.urihttps://doi.org/10.14744/ejmo.2017.06978
dc.identifier.urihttps://hdl.handle.net/11616/103905
dc.identifier.volume2en_US
dc.identifier.wosWOS:000604236000009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofEurasian Journal of Medicine and Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInversion 9en_US
dc.subjectkaryotypingen_US
dc.subjectMalatyaen_US
dc.subjectpolymorphismen_US
dc.titlePrevalence of Pericentric Inversion of Chromosome 9 in Eastern Anatolia Region and Relationship to Reproductive Efficiencyen_US
dc.typeArticleen_US

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