Expression of matrix metalloproteinases in gallbladder carcinoma andtheir significance in carcinogenesis
Yükleniyor...
Dosyalar
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Applied immunohistochemistry & Molecülar morphology
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The correlation between matrix metalloproteinase
(MMP)-2, MMP-9, and MMP-14 expression on the prognostic
parameters of gallbladder carcinoma (GBC) and their role in
carcinogenesis were evaluated. Carcinomas of the gallbladder
(n = 20) and chronic cholecystitis (n= 10) were studied for the
expression of MMP-2, MMP-9, and MMP-14 by immunohistochemistry.
In all of the cases, metaplastic and dysplastic
epithelial alterations, and (in GBC histologic type, grade of
differentiation, level of infiltration, perineural and angiolymphatic
invasion, liver invasion, and lymph node involvement
were noted. MMP-2, MMP-9, MMP-14 were expressed in
tumor epithelium in 9 (45%), 20 (100%), and 20 (100%) of the
cases, respectively. MMP stromal expression including muscle
layer, vascular endothelium, fibroblasts, and lymphoid cells were
detected in all cases. MMP-2 was not expressed in normal,
metaplastic, and dysplastic epithelia. In contrast, MMP-9 and
MMP-14 immunoreactivities were present in antral-type metaplastic
areas as moderate (grade 2) and strong in dysplastic
epithelia (grade 3). Only in mucinous-type GBC was the
expression of the MMPs lower than in the other types. No
significant correlation was detected with the grade of differentiation,
level of infiltration, perineural and angiolymphatic
invasion, liver invasion, or lymph node involvement. These data
suggest that MMP-9 and MMP-14 overexpression may have an
important role in tumorigenesis. MMP-2, MMP-9, and MMP-
14 were expressed in GBC epithelium but also the expression in
the stromal component may be essential for the malignant
potential of GBC.
Açıklama
Anahtar Kelimeler
MMP, Gallbladder, Cancer, Metaplasia, Dysplasia
Kaynak
Applied immunohistochemistry & Molecülar morphology
WoS Q Değeri
Scopus Q Değeri
Cilt
16
Sayı
Künye
Karadağ, N. Kırımlıoğlu, S. H. Işık, B. Yılmaz, S. Kırımlıoğlu, V. (2008). Expression of matrix metalloproteinases in gallbladder carcinoma andtheir significance in carcinogenesis. Applied immunohistochemistry & Molecülar morphology. 16:148–152.
