The Effects of HCV Infection on Serum Lipid Profile in Hemodialysis Patients

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dc.authoridSahin, Idris/0000-0002-8683-3737
dc.authorwosidŞahin, Hüseyin Avni/JWO-9166-2024
dc.authorwosidSahin, Idris/AAS-4390-2020
dc.contributor.authorSahin, Idris
dc.contributor.authorEminbeyli, Lokman
dc.contributor.authorSahin, Huseyin Avni
dc.contributor.authorKaba, Ismet
dc.date.accessioned2024-08-04T21:02:02Z
dc.date.available2024-08-04T21:02:02Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: We aimed to investigate effects of hepatitis C virus infection on serum lipid profile in hemodialyzed patients. Method: The serum lipid profile was determined in 108 patients who had been on regular hemodialysis for at least two months. Serum total cholesterol (TC), triglyceride (TG), HDL (high density lipoprotein), VLDL (very low density lipoprotein) and LDL (low density lipoprotein) levels were compared between two groups. Results: The study included 55 HCV- negative (% 58 male) and 53 HCV-positive (% 64 male) hemodialysed patients. Mean age was 43 +/- 16 years in the HCV- negative group and 43 +/- 14 years in the HCV- positive group. There were no significant differences between the two groups with respect to age and gender. Mean duration of HD was 20 +/- 16 months in the HCV (-) group and 50 +/- 32 months in the HCV (+) group. Mean hemodialysis time was longer in HCV (+) patients than HCV (-) patients (p<0.0001). Mean serum TC (129 +/- 27 vs 148 +/- 42 mg/dL; p=0.006), TG (137 +/- 55 vs 162 +/- 64 mg/dL; p=0.032), and HDL levels (32 +/- 11 vs 36 +/- 11 mg/dL; p=0.036) were significantly lower in the HCV-ositive group than in the HCV- negative group. Mean serum LDL and VLDL levels were similar in the two groups. Although we did not find a statistical difference between serum lipid levels and ALT levels; there was a statistically significant correlation between serum AST level and TC, TG, and VLDL-c levels. Serum TC, VLDL levels were significantly higher in patients with AST >30 iu/dL than in patients with AST <30 iu/dL. Conclusion: The present study suggests that HCV infection is associated with lower TC, TG and VLDL-c levels in hemodialysed patients. An increase in serum AST levels was associated with a decrease in lipid levels.en_US
dc.identifier.doi10.5262/tndt.2010.1001.06
dc.identifier.endpage45en_US
dc.identifier.issn1300-7718
dc.identifier.issue1en_US
dc.identifier.startpage40en_US
dc.identifier.urihttps://doi.org/10.5262/tndt.2010.1001.06
dc.identifier.urihttps://hdl.handle.net/11616/104402
dc.identifier.volume19en_US
dc.identifier.wosWOS:000217167600009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherTurk Nefroloji Diyaliz Transplantasyon Dergisien_US
dc.relation.ispartofTurkish Nephrology Dialysis and Transplantation Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHCVen_US
dc.subjectESRDen_US
dc.subjectLipiden_US
dc.subjectCholesterolen_US
dc.subjectHemodialysisen_US
dc.titleThe Effects of HCV Infection on Serum Lipid Profile in Hemodialysis Patientsen_US
dc.typeArticleen_US

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