Six year distribution pattern of hepatitis C virus in Turkey a multicentre study

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dc.authorid101949en_US
dc.contributor.authorAltındiş, Mustafa
dc.contributor.authorDal, Tuba
dc.contributor.authorAkyar, Işın
dc.contributor.authorKaratuna, Onur
dc.contributor.authorGökahmetoğlu, Selma
dc.contributor.authorTezcan Ülger, Seda
dc.contributor.authorKülah, Canan
dc.contributor.authorUzun, Berrin
dc.contributor.authorŞener, Aslı Gamze
dc.contributor.authorÖzdemir, Mehmet
dc.contributor.authorAydoğan, Sibel
dc.contributor.authorKuşkucu, Mert Ahmet
dc.contributor.authorMidilli, Kenan
dc.contributor.authorOtlu, Barış
dc.contributor.authorCelen, Mustafa Kemal
dc.contributor.authorBuruk, Kurtuluş
dc.contributor.authorGüdücüoğlu, Hüseyin
dc.date.accessioned2017-07-10T08:02:03Z
dc.date.available2017-07-10T08:02:03Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHepatitis C infection is a public health problem. The aim of this retrospective study was to determine the distribution of hepatitis C virus (HCV) genotypes in seven regions of Turkey, by evaluating 7002 patients with chronic HCV in a six-year period. During the 2009 2014 period, serum/plasma samples from 7002 new consecutive HCV RNA positive patients were collected. The female patients were 3867 (55.2%). The genotype distribution of HCV patiens was evaluated by ages and years. Statistical analysis was performed by using the Mann Whitney test and the x2 analysis. During the six-year period, genotype 1b was the most common genotype (67.7%) followed by untypeable genotype 1 (7.7%), genotype 4 (7.3%) and genotype 3 (6.7%). In 2014, genotype 3 was the second most common one (11.3%) and genotype 4 was the third most common one (9.8%). In the group with <25 years old patients, genotype 1b was most common (78.48%, 62/79) between the years of 2009 and 2011, whereas genotype 3 (34.8%, 86/247), between the years of 2012 and 2014. Genotype 1b was the most common in the groups between 26 and 35 years, 36 and 45 years, 46 and 55 years, 56 and 65 years. The rate of genotype 3 was increased from 4.78% to 10.06% and the rate of genotype 4 was increased from 1.3% to 3.84%, from 2009 2011 to 2012 2014. In recent years, genotypes 3 and 4 have gained importance. New therapeutic strategies and survey studies may be required for the modified HCV genotype pattern.en_US
dc.identifier.citationAltındiş, M. Dal, T. Akyar, I. Karatuna, O. Gökahmetoğlu, S. Tezcan Ülger, S. Külah, C. Uzun, B. Şener, A. G. Özdemir, M. Aydoğan, S. Kuşkucu, M. A. Midilli, K. Otlu, B. Celen, M. K. Buruk, K. Güdücüoğlu, H. (2015). Six year distribution pattern of hepatitis C virus in Turkey a multicentre study. Biotechnology & Biotechnological Equipment. 30, 2; 335,340.en_US
dc.identifier.doi10.1080/13102818.2015.1093430en_US
dc.identifier.endpage340en_US
dc.identifier.issn1310-2818
dc.identifier.issue2en_US
dc.identifier.startpage335en_US
dc.identifier.urihttp://www.tandfonline.com/doi/full/10.1080/13102818.2015.1093430
dc.identifier.urihttps://hdl.handle.net/11616/7354
dc.identifier.volume30en_US
dc.language.isoenen_US
dc.publisherBiotechnology & Biotechnological Equipmenten_US
dc.relation.ispartofBiotechnology & Biotechnological Equipmenten_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHepatitis Cen_US
dc.subjectGenotypesen_US
dc.subjectTurkeyen_US
dc.titleSix year distribution pattern of hepatitis C virus in Turkey a multicentre studyen_US
dc.typeArticleen_US

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