Progesterone Inhibits Human Myometrial Contractions by its Action on Membrane Receptors

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dc.contributor.authorGokdeniz, Remzi
dc.contributor.authorOvayolu, Ali
dc.contributor.authorGarfield, Robert E.
dc.date.accessioned2024-08-04T21:00:55Z
dc.date.available2024-08-04T21:00:55Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: The mechanisms for myometrial inhibition are still being investigated. The aim of this article is to examine mechanisms of progesterone (P4) inhibition of uterine contractility. Methods: Prospective study Tertiary care center at St. Joseph's Hospital and at Maricopa Hospital, Phoenix, AZ and research center in Arizona, USA. During 2010-2011 24 women were given birth by cesarean section. Uterine tissues from women (n= 24) at term were suspended in organ chambers and exposed to various agents. Contractility was recorded and compared before and after addition of agents. Tissues were treated with P4 alone, a progestin (R5020) with low affinity to the progesterone membrane receptor (mPR), or a non-sex steroid (cholesterol). Other tissues were pretreated with inhibitors of adenylate cyclase (SQ 22536), phosphodiesterase (rolipram), nitric oxide ( NO) synthases (L-NAME) or a nuclear P4 receptor antagonist (mifepristone, MIF), followed by P4. Data were analyzed by ANOVA. Results: P4 (P< 0.05) inhibits uterine contractions. R5020 and cholesterol have little P> 0.05) inhibitory effects. P4 inhibition is not blocked by MIF, SQ, ODQ, rolipram or L-NAME ( P> 0.05). Conclusions: P4 rapidly inhibits myometrial contractility by nongenomic mechanisms through action on mPR but not via cAMP, cGMP, or NOen_US
dc.description.sponsorshipSt. Joseph's Research Foundationen_US
dc.description.sponsorshipFunding for this study was supported by the St. Joseph's Research Foundation: see above under Acknowledgements.en_US
dc.identifier.endpage102en_US
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue1en_US
dc.identifier.startpage92en_US
dc.identifier.urihttps://hdl.handle.net/11616/103924
dc.identifier.volume38en_US
dc.identifier.wosWOS:000216438000012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherCukurova Univ, Fac Medicineen_US
dc.relation.ispartofCukurova Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyclic adenosine monophosphateen_US
dc.subjectmyometriumen_US
dc.subjectpreterm laboren_US
dc.subjectprogesterone receptorsen_US
dc.subjectuterine contractilityen_US
dc.titleProgesterone Inhibits Human Myometrial Contractions by its Action on Membrane Receptorsen_US
dc.typeArticleen_US

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