The mechanical or electrical induction of medullary angiogenesis - Will it improve sternal wound healing?

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dc.authoridAlat, Ilker/0000-0003-1860-7620
dc.authoridInan, Mehmet/0000-0003-1806-7927
dc.authorwosidAlat, Ilker/AAQ-6262-2021
dc.authorwosidInan, Mehmet/Q-6453-2019
dc.contributor.authorAlat, I
dc.contributor.authorInan, M
dc.contributor.authorGurses, I
dc.contributor.authorKekilli, E
dc.contributor.authorGermen, B
dc.contributor.authorHarma, A
dc.contributor.authorEskin, A
dc.date.accessioned2024-08-04T21:02:06Z
dc.date.available2024-08-04T21:02:06Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description4th Experimental and Clinical Research Congress -- MAY, 2003 -- Kayseri, TURKEYen_US
dc.description.abstractWe induced angiogenesis in the tibial medulla and cortex of rabbits by electrical and mechanical stimulation, with the aim of future application to ischemic disease. Sixteen New Zealand rabbits were divided into 4 groups: in Group 1, a wire was inserted into the medullary channel; in Group 2 a hole was drilled into the tibia; in Group 3, electrical stimulation was applied to the medullary channel; and in Group 4 (the control group), nothing was done. The interventions were applied during a 21-day period, after which all animals were evaluated scintigraphically and histopathologically. All 3 interventional groups were significantly superior to the control group in regard to medullary and cortical vascularity: the P values were 0.021 in all comparisons to control. However the most fibrotic changes in the medulla occurred in the group that had been treated with electricity (P=0.008). Slight fibrotic changes occurred in the hole group (P=0.040), and none occurred in the K-wire group. In sum, all 3 interventions are capable of inducing medullary angiogenesis, but electricity is inferior in regard to fibrotic change. We believe that this present study can establish a baseline for further work that explores clinical applications to problematic ischemic conditions, including delayed sternal wound healing after cardiac surgery.en_US
dc.identifier.endpage367en_US
dc.identifier.issn0730-2347
dc.identifier.issn1526-6702
dc.identifier.issue4en_US
dc.identifier.pmid15745286en_US
dc.identifier.startpage363en_US
dc.identifier.urihttps://hdl.handle.net/11616/104482
dc.identifier.volume31en_US
dc.identifier.wosWOS:000225746300005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTexas Heart Insten_US
dc.relation.ispartofTexas Heart Institute Journalen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectangiogenesisen_US
dc.subjectbone regenerationen_US
dc.subjectelectric stimulation therapyen_US
dc.subjectneovascularization, physiologicen_US
dc.subjectsternum/blood supplyen_US
dc.subjectsurgical wound dehiscence/prevention & controlen_US
dc.subjectwound healing/physiologyen_US
dc.titleThe mechanical or electrical induction of medullary angiogenesis - Will it improve sternal wound healing?en_US
dc.typeConference Objecten_US

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