Thrombopoietic cytokines in patients with iron deficiency anemia with or without thrombocytosis

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dc.authoridArat, Mutlu/0000-0003-2039-8557
dc.authoridBeksac, Meral/0000-0003-1797-8657
dc.authoriddalva, klara/0000-0001-6917-6870
dc.authorwosidArat, Mutlu/AAI-1481-2019
dc.authorwosidBeksac, Meral/D-6411-2013
dc.authorwosiddalva, klara/AAN-7704-2020
dc.contributor.authorAkan, H
dc.contributor.authorGüven, N
dc.contributor.authorAydogdu, I
dc.contributor.authorArat, M
dc.contributor.authorBeksaç, M
dc.contributor.authorDalva, K
dc.date.accessioned2024-08-04T21:02:16Z
dc.date.available2024-08-04T21:02:16Z
dc.date.issued2000
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIron deficiency anemia is a cause of reactive thrombocytosis. A moderate increase in platelet numbers is common but sometimes counts may exceed 1,000 x 10(9)/1. The mechanisms causing reactive thrombocytosis are unclear. In this study, we evaluated 15 women with iron deficiency anemia and thrombocytosis (platelets >450 x 10(9)/1) and 16 women with iron deficiency anemia with normal platelet counts. Serum samples were taken before oral iron replacement therapy, after 1 and 3 months and at the end of replacement therapy. Thrombopoietin, erythropoietin (EPO), leukemia inhibitory factor, interleukin-6 and interleukin-11 levels were assayed. There was no change in the levels of thrombopoietic cytokines except for EPO. The correlation between high EPO levels and high platelet counts may suggest that EPO increases platelet counts, but the same EPO revel changes can also be demonstrated in women with iron deficiency anemia but normal initial platelet counts. The fact that the levels of other cytokines remained unchanged during treatment suggests that either these cytokines have no effect on reactive thrombocytosis or the change in platelet counts in our patients is in a narrow range and is thus not affected by the cytokine levels. Copyright (C) 2000 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000041038
dc.identifier.endpage156en_US
dc.identifier.issn0001-5792
dc.identifier.issn1421-9662
dc.identifier.issue3en_US
dc.identifier.pmid10940653en_US
dc.identifier.startpage152en_US
dc.identifier.urihttps://doi.org/10.1159/000041038
dc.identifier.urihttps://hdl.handle.net/11616/104618
dc.identifier.volume103en_US
dc.identifier.wosWOS:000088768000004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofActa Haematologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecterythropoietinen_US
dc.subjectinterleukin 6en_US
dc.subjectinterleukin 11en_US
dc.subjectiron deficiency anemiaen_US
dc.subjectleukemia inhibitory factoren_US
dc.subjectthrombopoietinen_US
dc.titleThrombopoietic cytokines in patients with iron deficiency anemia with or without thrombocytosisen_US
dc.typeArticleen_US

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