Body Mass Index is Associated with Immunohistochemical Nuclear Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) Expression in Stage IB-IC Endometrioid Endometrial Carcinoma

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dc.authoridAydin Kose, Fadime/0000-0001-5222-7555
dc.authorwosidAydin Kose, Fadime/X-6550-2019
dc.contributor.authorMeydanli, Mutlu
dc.contributor.authorKaradag, Nese
dc.contributor.authorKose, Faruk
dc.contributor.authorTulunay, Gokhan
dc.contributor.authorOzfuttu, Ahrnet
dc.date.accessioned2024-08-04T20:57:18Z
dc.date.available2024-08-04T20:57:18Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To examine the relationship between clinicopathologic features and nuclear phosphatase and tensin homolog deleted on chromosome 10 (PTEN) expression in a homogeneous group of Stage IB-IC sporadic endometrioid endometrial cancer (EEC) patients. Materials and Methods: This study was conducted on 65 consecutive EEC patients with FIGO Stage IB-IC disease who underwent initial complete surgical staging. Age, body mass index (BMI), tumor grade, immunohistochemical nuclear PTEN expression and clinical outcome were examined. The median follow-up period was 49 months (range, 8 to 78 months). Results: Immunohistochemical staining revealed positive nuclear PTEN expression in 20 cases (30.8%). Nuclear PTEN was found out to be reduced in 36 cases (55.4%), whereas it was completely lost in nine cases (13.8%). After evaluating the staining status, 45 cases (69.2%) were judged as negative for nuclear PTEN expression. During the follow-up period, clinical recurrence of disease was documented in five of 65 women (7.7%). The 5-year disease free survival rate for patients with positive nuclear PTEN expression was similar to that for patients with negative nuclear PTEN expression (75.2% vs. 91.3%, respectively; p =0.728 [log-rank test]). The mean body mass index (BMI) of positive nuclear PTEN expressing cases was significantly greater than that of patients with negative nuclear PTEN expression (32.5 +/- 6.5 vs. 28.5 +/- 5.0, respectively; p =0.009). Discussion: Lost/reduced nuclear PTEN expression was frequent in FIGO Stage IB/IC EEC. BMI is the only clinicopathologic variable affecting immunohistochemical nuclear PTEN expression.en_US
dc.description.sponsorshipManagement Unit of Scientific Investigation Projects, Inonii University [2003/41]en_US
dc.description.sponsorshipThis study was supported by the grants from The Management Unit of Scientific Investigation Projects, Inonii University (2003/41).en_US
dc.identifier.endpage414en_US
dc.identifier.issn1309-0399
dc.identifier.issn1309-0380
dc.identifier.issue4en_US
dc.identifier.startpage408en_US
dc.identifier.urihttps://hdl.handle.net/11616/102496
dc.identifier.volume8en_US
dc.identifier.wosWOS:000420591600010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofJournal of The Turkish-German Gynecological Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectnuclear PTEN expressionen_US
dc.subjectimmunohistochemistryen_US
dc.subjectbody mass indexen_US
dc.subjectendometrial canceren_US
dc.titleBody Mass Index is Associated with Immunohistochemical Nuclear Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) Expression in Stage IB-IC Endometrioid Endometrial Carcinomaen_US
dc.typeArticleen_US

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