Serum Interleukin-6 Levels in the Differential Diagnosis of Sepsis and Transient Tachypnea of Newborn

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dc.authoridTatli, Mustafa Mansur/0000-0003-2767-3734
dc.authorwosidUras, Nurdan/AAR-5383-2020
dc.authorwosidTatli, Mansur M/E-6160-2016
dc.authorwosidTONBUL, ALPARSLAN/N-1115-2015
dc.contributor.authorUras, Nurdan
dc.contributor.authorKaradag, Ahmet
dc.contributor.authorTonbul, Alparslan
dc.contributor.authorMete, Emin
dc.contributor.authorKara, Semra
dc.contributor.authorKarabel, Musemma
dc.contributor.authorTatli, Mustafa Mansur
dc.date.accessioned2024-08-04T21:01:08Z
dc.date.available2024-08-04T21:01:08Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to evaluate the role of serum interleukin-6 (IL-6) levels in the differentiation of neonatal bacterial sepsis and TTN. Material and Methods: The hospital records of 58 newborn infants with respiratory distress who were above 35 weeks of gestational age were investigated. Patients were divided into two groups. The infection group consisted of patients with proven sepsis and clinical sepsis and the other was the UN group. Clinical findings and white blood cell count, serum C-reactive protein (CRP), IL-6 levels and the ratio of immature neutrophils to total neutrophils count (UT) were recorded and compared between the two groups. Results: Serum CRP and IL-6 levels were found higher than the normal limits in both of the groups. However there was no significant difference between them. Duration of respiratory distress was longer and I/T ratio significantly higher in the infection group than the UN group. The combination of IL-6 and I/T ratio yielded a sensitivity of 80%, a specificity of 48%, a positive predictive value of 44.7%, and a negative predictive value of 80% Conclusion: The I/T ratio and IL-6 may contribute to the early diagnosis of sepsis with respiratory symptoms in newborn infants but IL-6 alone cannot distinguish between TIN and sepsis.en_US
dc.identifier.doi10.5174/tutfd.2009.01548.2
dc.identifier.endpage366en_US
dc.identifier.issn1301-3149
dc.identifier.issue4en_US
dc.identifier.startpage363en_US
dc.identifier.urihttps://doi.org/10.5174/tutfd.2009.01548.2
dc.identifier.urihttps://hdl.handle.net/11616/104112
dc.identifier.volume27en_US
dc.identifier.wosWOS:000287686200008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAves Yayincilik, Ibrahim Karaen_US
dc.relation.ispartofTrakya Universitesi Tip Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectinterleukin 6en_US
dc.subjectsepsisen_US
dc.subjectnewbornen_US
dc.subjecttransient tachypneaen_US
dc.titleSerum Interleukin-6 Levels in the Differential Diagnosis of Sepsis and Transient Tachypnea of Newbornen_US
dc.typeArticleen_US

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