Aptamers an in vitro evolution of therapeutic and diagnostic applications in medicine
Yükleniyor...
Dosyalar
Tarih
2013
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Disease and Molecular Medicine
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aptamers are nucleic acid oligomers with distinct conformational shapes that allow
binding targets with high affinity and specificity. Selective Evolution of Ligands by Exponential
Enrichment (SELEX); an in vitro selection process to develop aptamers, has been
invented in 1990. Despite more than 20 years have passed after its discovery, products
of SELEX technology are in use in medicine. In this review we discuss why we need aptamers
not only in therapeutic but also in diagnostic applications; and also critical points
in SELEX technology. Finally; we present the aptamers in use and some patented aptamers
awaiting approval.
Açıklama
Anahtar Kelimeler
Aptamer, SELEX, Medicine
Kaynak
Disease and Molecular Medicine
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
1
Künye
Kayhan, B. Kayabaş, Ü. (2013). Aptamers an in vitro evolution of therapeutic and diagnostic applications in medicine. Disease and Molecular Medicine. 1; 54-60.
