The effects of disease severity and comorbidity on oxidative stress biomarkers in obstructive sleep apnea

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dc.authoridErdem, Mehmet/0000-0002-9100-2479
dc.authoridIN, ERDAL/0000-0002-8807-5853
dc.contributor.authorKiran, Tugba Raika
dc.contributor.authorOtlu, Onder
dc.contributor.authorErdem, Mehmet
dc.contributor.authorGeckil, Aysegul Altintop
dc.contributor.authorBerber, Nurcan Kirici
dc.contributor.authorIn, Erdal
dc.date.accessioned2024-08-04T21:02:02Z
dc.date.available2024-08-04T21:02:02Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurposeIschemia-modified albumin (IMA), total oxidant status (TOS), and total antioxidant status (TAS) are biomarkers used to evaluate oxidative stress status in various diseases including obstructive sleep apnea (OSA). In this study, we investigated the effects of disease severity and comorbidity on IMA, TOS and TAS levels in OSA.MethodsPatients with severe OSA (no-comorbidity, one comorbidity, and multiple comorbidities) and mild-moderate OSA (no-comorbidity, one and multiple comorbidities), and healthy controls were included in the study. Polysomnography was applied to all cases and blood samples were taken from each participant at the same time of day. ELISA was used to measure IMA levels in serum samples and colorimetric commercial kits were used to perform TOS and TAS analyses. In addition, routine biochemical analyses were performed on all serum samples.ResultsA total of 74 patients and 14 healthy controls were enrolled. There was no statistically significant difference between the disease groups according to gender, smoking status, age, body mass index (BMI), HDL, T3, T4, TSH, and B12 (p > 0.05). As the severity of OSA and comorbidities increased, IMA, TOS, apnea-hypopnea index (AHI), desaturation index (T90), cholesterol, LDL, triglyceride, AST, and CRP values increased significantly (p < 0.05). On the other hand, TAS, minimum desaturation, and mean desaturation values decreased significantly (p < 0.05).ConclusionsWe concluded that IMA, TOS, and TAS levels may indicate OSA-related oxidative stress, but as the severity of OSA increases and with the presence of comorbidity, IMA and TOS levels may increase and TAS levels decrease. These findings suggest that disease severity and presence/absence of comorbidity should be considered in studies on OSA.en_US
dc.identifier.doi10.1007/s11325-023-02870-9
dc.identifier.endpage163en_US
dc.identifier.issn1520-9512
dc.identifier.issn1522-1709
dc.identifier.issue1en_US
dc.identifier.pmid37430029en_US
dc.identifier.startpage151en_US
dc.identifier.urihttps://doi.org/10.1007/s11325-023-02870-9
dc.identifier.urihttps://hdl.handle.net/11616/104398
dc.identifier.volume28en_US
dc.identifier.wosWOS:001025581700001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofSleep and Breathingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschemia-modified albuminen_US
dc.subjectObstructive sleep apnea syndromeen_US
dc.subjectOxidative stressen_US
dc.subjectPolysomnographyen_US
dc.subjectTotal oxidant statusen_US
dc.subjectTotal antioxidant statusen_US
dc.titleThe effects of disease severity and comorbidity on oxidative stress biomarkers in obstructive sleep apneaen_US
dc.typeArticleen_US

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