GENOTOXICITY TESTING OF TRIBUTYLTIN AND METHIDATHION IN DROSOPHILA MELANOGASTER USING THE WING SOMATIC MUTATION AND RECOMBINATION TEST

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dc.authoridYesilada, Elif/0000-0002-3743-5767
dc.authorwosidYesilada, Elif/ABG-9600-2020
dc.contributor.authorKarabulut, Aygul Kilic
dc.contributor.authorYesilada, Elif
dc.date.accessioned2024-08-04T20:58:53Z
dc.date.available2024-08-04T20:58:53Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, genotoxic effects of tributyltin (TBT) and methidathion (MD) were investigated using Drosophila wing somatic mutation and recombination test (SMART). This test is based on the principle that the loss of heterozygosity of suitable recessive marker hairs such as multiple wing (mwh) and flare-3 (flr(3)), can lead to the formation of mutant clones of larval cells, which are then expressed as spots on the wings of the adult flies. Third-instar larvae that were trans-heterozygous for the two genetic markers mwh and flr(3) were treated at different doses (0,1 mg/L, 1 mg/L, 10 mg/L, 30 mg/L, and 50 mg/L of TBT and 0.01 mg/L, 0.025 mg/L, 0.05 mg/L, 0.06 mg/L, and 0.075 mg/L of MD) of the test compounds. Mitomycin C (MMC), a commonly known mutagen, was used as positive control. The results indicated that highest experimental dose of TBT showed toxic and genotoxic effects, including recombinogenic activity in the marker-heterozygous flies. However, based on our results, MD showed no genotoxicity in the SMART assay, an in vivo model.en_US
dc.description.sponsorshipInonu University [BAP 2011-171]en_US
dc.description.sponsorshipThis work (Project no. BAP 2011-171) was financially supported by Inonu University.en_US
dc.identifier.endpage3481en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue12Cen_US
dc.identifier.startpage3476en_US
dc.identifier.urihttps://hdl.handle.net/11616/103259
dc.identifier.volume23en_US
dc.identifier.wosWOS:000349805700009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGenotoxicityen_US
dc.subjectDrosophila melanogasteren_US
dc.subjectSMARTen_US
dc.subjectTributyltin (TBT)en_US
dc.subjectMethidathion (MD)en_US
dc.subjectMitomycin-C (MMC)en_US
dc.titleGENOTOXICITY TESTING OF TRIBUTYLTIN AND METHIDATHION IN DROSOPHILA MELANOGASTER USING THE WING SOMATIC MUTATION AND RECOMBINATION TESTen_US
dc.typeArticleen_US

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