Perioperative High-Dose Amiodarone Elevates Nitric Oxide Levels in Patients Undergoing Coronary Artery Bypass Surgery.

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dc.authoridBurma, Oktay/0000-0002-0880-4578
dc.authoriduysal, ayhan/0000-0001-7526-5554
dc.authoridUstundag, Bilal/0000-0001-6621-2450
dc.authoridozguler, ibrahim murat/0000-0002-9928-9056
dc.authorwosidOzgüler, Murat/W-4262-2018
dc.authorwosidColak, M. Cengiz/ABI-3394-2020
dc.authorwosidÜSTÜNDAĞ, BİLAL/V-9780-2018
dc.authorwosidBurma, Oktay/W-4151-2018
dc.authorwosidUysal, Ayhan/W-5118-2018
dc.contributor.authorUysal, Ayhan
dc.contributor.authorAzak, Soner
dc.contributor.authorColak, M. Cengiz
dc.contributor.authorBurma, Oktay
dc.contributor.authorOzguler, I. Murat
dc.contributor.authorUstundag, Bilal
dc.contributor.authorBayar, Mustafa Kemal
dc.date.accessioned2024-08-04T21:00:09Z
dc.date.available2024-08-04T21:00:09Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of the current study was to assess the effects of the Class III antiarrhythmic drug amiodarone on arterial blood Nitric oxide (NO) levels together with malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-px), and catalase (CAT) levels in patients undergoing coronary artery bypass surgery (CABG). Twenty patients undergoing CABG were included in the study. The patients were divided into control and amiodarone groups (n=10 in each group). The patients in group 1 did not receive any drugs. The patients in group II received 4X400 mg/day amiodarone on the day before surgery, 2X600 mg/day amiodarone on the day of surgery, and 2X400 mg/day amiodarone for the first consecutive four days after the surgery. NO, MDA, SOD, GSH-px, and CAT values were measured for biochemical evaluation of oxidative stress before the induction of anesthesia (T-A), before CPB (T-CPB), five minutes after the clamp was removed (T-c), after protamine (T-P), and on postoperative days 1 (T-1), 3 (T-3), and 5 (T-5). Hemodynamic changes of all patients were recorded at before the induction of anesthesia (TA), before CPB (TCPB), after protamine (T-P), and on postoperative day 1 (T1). Amiodarone elevated NO levels at all times during the study period but did not cause changes in MDA, SOD, GSH-px, or CAT. In addition, amiodarone decreased mean pulmonary artery pressure, pulmonary capillary wedge pressure, and heart rate in these patients. No side effect due to drug was observed. Heart rate was found more decreased in amiodarone group at T-1 and T-2 stages when compared with controls (p<0.05). Perioperative high- dose amiodarone might be beneficial for patients who are pulmonary hypertensive and are undergoing CABG.en_US
dc.identifier.endpage492en_US
dc.identifier.issn0970-938X
dc.identifier.issn0976-1683
dc.identifier.issue4en_US
dc.identifier.startpage486en_US
dc.identifier.urihttps://hdl.handle.net/11616/103842
dc.identifier.volume24en_US
dc.identifier.wosWOS:000325694600013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAllied Acaden_US
dc.relation.ispartofBiomedical Research-Indiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmiodaroneen_US
dc.subjectcoronary bypass surgeryen_US
dc.subjectnitric oxideen_US
dc.titlePerioperative High-Dose Amiodarone Elevates Nitric Oxide Levels in Patients Undergoing Coronary Artery Bypass Surgery.en_US
dc.typeArticleen_US

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