Beneficial effects of taurine on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced oxidative and histopathological damage in the heart tissue of rats

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dc.contributor.authorCiftci, Osman
dc.contributor.authorKaplan, Munevver Nazlican
dc.contributor.authorBasak Turkmen, Nese
dc.contributor.authorCetin, Asli
dc.contributor.authorCiftci, Bedriye
dc.contributor.authorAyhan, Idris
dc.date.accessioned2026-04-04T13:33:15Z
dc.date.available2026-04-04T13:33:15Z
dc.date.issued2026
dc.departmentİnönü Üniversitesi
dc.description.abstractThis study investigated the protective effects of taurine against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced cardiotoxic damage in rats. Adult male Wistar rats (250-300 g) were randomly assigned to four groups (n = 8 per group): Control, TCDD, TAU, and TCDD + TAU. TCDD (2 mu g/kg/week) and/or taurine (200 mg/kg/day) were administered via gavage for 30 days. Following the experimental period, heart tissue samples were collected for analysis. Oxidative stress parameters, including thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD) activity, and glutathione (GSH) levels, were assessed using biochemical methods. Histopathological and immunohistochemical evaluations of cardiac tissue were also performed. The TCDD group showed significantly increased TBARS levels (p < 0.05) and decreased SOD activity and GSH levels (p < 0.001) compared with the Control group. In contrast, taurine co-administration significantly increased SOD activity and GSH levels while reducing TBARS levels relative to the TCDD group. Moreover, TCDD exposure induced marked histopathological alterations in heart tissue, whereas taurine co-administration attenuated these structural alterations. Immunohistochemical findings indicated that taurine attenuated TCDD-induced apoptosis by reducing caspase-3 activation. Overall, taurine effectively mitigated TCDD-induced oxidative stress, histopathological damage, and apoptotic signaling in cardiac tissue, suggesting that taurine co-administration may exert protective effects against TCDD-induced cardiotoxicity.
dc.identifier.doi10.1177/07482337261436345
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.pmid41869782
dc.identifier.urihttps://doi.org/10.1177/07482337261436345
dc.identifier.urihttps://hdl.handle.net/11616/109027
dc.identifier.wosWOS:001720636000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofToxicology and Industrial Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250329
dc.subjectTCDD
dc.subjectcardiotoxicity
dc.subjectoxidative stress
dc.subjecttaurine
dc.titleBeneficial effects of taurine on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced oxidative and histopathological damage in the heart tissue of rats
dc.typeArticle

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