Apoptotic, Cytotoxic and Antimigratory Activities of Phenolic Compounds

Basit Öğe Kaydı
dc.contributor.authorYuce, H.
dc.contributor.authorSahin, Y.
dc.contributor.authorTurkmen, N. Basak
dc.contributor.authorOzek, D. Askin
dc.contributor.authorUnuvar, S.
dc.contributor.authorCiftci, O.
dc.date.accessioned2024-08-04T20:56:30Z
dc.date.available2024-08-04T20:56:30Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe objective of this study was to evaluate the biological activities of chrysin (CRY), curcumin (CUR), and ellagic acid (EA) by comparing the anti-proliferative, anti-migration effects, and apoptotic gene expressions between the three human cancer cell lines: lung (A549), liver (HEP3B), and breast (MCF-7) compared to normal human fibroblast cell line (L929). Antiproliferative effects of certain phenolic compounds were determined by the MTS assay. Cells were treated with different concentrations of the compounds for two consecutive days. Their effect on cell migration was evaluated using the wound-healing assay. Apoptosis was evaluated by Bax, Bcl-2, Cas-3, Cas-8, Cas-9, Cas-10, CDK 2, CDK4, CDK6, CCNB1, and CCND2 gene expressions. The MTS assay showed that the compounds had antiproliferative effects on A549, HEP3B, and MCF-7 cell lines in a dose- and time-dependent manner. All three compounds also suppressed the migration of the tumor cell lines, significantly increased the levels of apoptotic gene expression, and induced apoptotic cell death. This study shows that chrysin, curcumin, and ellagic acid could be considered promising chemotherapeutic agents in the treatment of lung, liver, and breast cancers.en_US
dc.identifier.doi10.1134/S0022093022060138
dc.identifier.endpage1833en_US
dc.identifier.issn0022-0930
dc.identifier.issn1608-3202
dc.identifier.issue6en_US
dc.identifier.startpage1819en_US
dc.identifier.urihttps://doi.org/10.1134/S0022093022060138
dc.identifier.urihttps://hdl.handle.net/11616/102383
dc.identifier.volume58en_US
dc.identifier.wosWOS:000903282700013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherPleiades Publishing Incen_US
dc.relation.ispartofJournal of Evolutionary Biochemistry and Physiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchrysinen_US
dc.subjectcurcuminen_US
dc.subjectellagic aciden_US
dc.subjectapoptosisen_US
dc.subjectantiproliferative effecten_US
dc.subjectcell migrationen_US
dc.subjectlung canceren_US
dc.subjecthepatomaen_US
dc.subjectbreast canceren_US
dc.subjectfibroblastsen_US
dc.titleApoptotic, Cytotoxic and Antimigratory Activities of Phenolic Compoundsen_US
dc.typeArticleen_US

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