Management of pancreatic head adenocarcinoma: From where to where?

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dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.contributor.authorDolay, Kemal
dc.contributor.authorMalya, Fatma Umit
dc.contributor.authorAkbulut, Sami
dc.date.accessioned2024-08-04T20:59:55Z
dc.date.available2024-08-04T20:59:55Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPancreatic head adenocarcinoma (PHAC) is one of the most aggressive malignancies, and it has low long-term survival rates. Surgery is the only option for long-term survival. The difficulties associated with PHAC include higher frequencies of regional or distant lymph node metastases and vascular involvement, and positive resection margins in pancreatic and retroperitoneal tissues. Radical resections increase margin negativity and life expectancy; however, the extend of the surgery applied is controversial. Thus, western and eastern centers may use different approaches. Multiorgan, peripancreatic nerve plexus, and vascular resections have been discussed in relation to radical surgery for pancreatic cancer as have the roles of neoadjuvant and adjuvant therapy regimens. Determining the appropriate limits for surgery, standardizing definitions and surgical techniques according to guidelines, and centralizing pancreatic surgery within high-volume institutions to reduce mortality and morbidity rates are among the most important issues to consider. In this review, we evaluate the basic concepts underlying and the roles of radical surgery for PHAC, and lymphadenectomy, nerve plexus, retroperitoneal tissue, vascular, and multivisceral resections, total pancreatectomy, and liver metastases are discussed.en_US
dc.identifier.doi10.4240/wjgs.v11.i3.143
dc.identifier.endpage154en_US
dc.identifier.issn1948-9366
dc.identifier.issue3en_US
dc.identifier.pmid31057699en_US
dc.identifier.startpage143en_US
dc.identifier.urihttps://doi.org/10.4240/wjgs.v11.i3.143
dc.identifier.urihttps://hdl.handle.net/11616/103649
dc.identifier.volume11en_US
dc.identifier.wosWOS:000465470700004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBaishideng Publishing Group Incen_US
dc.relation.ispartofWorld Journal of Gastrointestinal Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPancreatic head canceren_US
dc.subjectStandard pancreatectomyen_US
dc.subjectExtended pancreatectomyen_US
dc.subjectRegional lymphadenectomyen_US
dc.subjectExtended lymphadenectomyen_US
dc.titleManagement of pancreatic head adenocarcinoma: From where to where?en_US
dc.typeReview Articleen_US

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