NEOPTERIN AND RECURRENT SPONTANEOUS ABORTION (RSA): THE EFFECT OF CELLULAR IMMUNE SYSTEM ACTIVATION ON SUBSEQUENT PREGNANCY

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dc.authoridÜnüvar, Songül/0000-0001-8454-490X
dc.authorwosidÜnüvar, Songül/ABH-5516-2020
dc.contributor.authorUnuvar, Songul
dc.contributor.authorTanriverdi, Zubeyde
dc.date.accessioned2024-08-04T21:00:02Z
dc.date.available2024-08-04T21:00:02Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.descriptionInternational Conference of Central-Bohemia-University (CBUIC) - Innovations in Science and Education -- MAR 22-24, 2017 -- Prague, CZECH REPUBLICen_US
dc.description.abstractBackground: Recurrent miscarriages are common complications in pregnancy. Neopterin is one of the immunologic biomarkers of several diseases related to activation of the cellular immune system. RSA is associated with immune system related abnormalities. Objectives: We aimed to investigate the effectiveness of neopterin levels in the early diagnosis of RSA. Methods: Eighty RSA patients and forty-three healthy controls were included in the study. The neopterin concentrations were determined by the enzyme-linked immunosorbent assay (ELISA) method. For the statistical analysis, Mann-Whitney U test and Pearson correlation test were used the; p<0.05 was considered statistically significant. Results: Serum mean neopterin levels were 16.47 +/- 0.095 nmol/L in RSA group and 6.14 +/- 0.041 nmol/L in control group, respectively. Compared to the control group, a statistically significant increase (p=0.0183) in the serum neopterin levels of the patients was observed. There was a negative correlation between serum neopterin level and age in both the control (R=0.0774, p=0.6236) and RSA groups (R=0.1415, p=0.2089). However, this correlation was not statistically significant (p>0.05). Conclusions: With overstimulation of interferon-gamma (INF-gamma) during pregnancy, the production of neopterin increases by monocytes/macrophages. The measurement of neopterin levels in the serum contributes to the early diagnosis of pregnancy losses.en_US
dc.description.sponsorshipCent Bohemia Univ,Unicorn Collen_US
dc.identifier.doi10.12955/cbup.v5.1065
dc.identifier.endpage1031en_US
dc.identifier.isbn978-80-88042-08-2
dc.identifier.issn1805-997X
dc.identifier.issn1805-9961
dc.identifier.startpage1028en_US
dc.identifier.urihttps://doi.org/10.12955/cbup.v5.1065
dc.identifier.urihttps://hdl.handle.net/11616/103743
dc.identifier.volume5en_US
dc.identifier.wosWOS:000439408200179en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherCentral Bohemia Univen_US
dc.relation.ispartofCbu International Conference Proceedings 2017: Innovations in Science and Educationen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPregnancyen_US
dc.subjectneopterinen_US
dc.subjectINF-gammaen_US
dc.titleNEOPTERIN AND RECURRENT SPONTANEOUS ABORTION (RSA): THE EFFECT OF CELLULAR IMMUNE SYSTEM ACTIVATION ON SUBSEQUENT PREGNANCYen_US
dc.typeConference Objecten_US

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