The protective effects of physiological and pharmacological concentrations of melatonin on renal ischemia-reperfusion injury in rats

Basit Öğe Kaydı
dc.authoridAcet, Ahmet/0000-0003-1131-1878
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridCigremis, Yilmaz/0000-0002-8600-0946
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authorwosidAcet, Ahmet/AAB-3273-2021
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidCigremis, Yilmaz/O-6019-2015
dc.authorwosidOzturk, Feral/A-2678-2016
dc.authorwosidCigremis, Yilmaz/JAC-8451-2023
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.contributor.authorSahna, E
dc.contributor.authorParlakpinar, H
dc.contributor.authorOzturk, F
dc.contributor.authorCigremis, Y
dc.contributor.authorAcet, A
dc.date.accessioned2024-08-04T21:02:09Z
dc.date.available2024-08-04T21:02:09Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractReactive oxygen species have been implicated in the pathophysiology of renal ischemia reperfusion (I/R) injury. The pineal secretory product melatonin is known to be a potent free radical scavenger and antioxidant. This study was designed to investigate the effects of physiological and pharmacological concentrations of melatonin on I/R injury. Rats were pinealectomized (Px) or sham-operated (control) 2 months before the I/R studies. There were eight groups of eight rats each. After a right nephrectomy to produce damage, left renal vessels were occluded for 60 min, followed by 24 h reperfusion, in rats. Malondialdehyde (MDA) levels resulting from I/R were significantly higher in the pinealectomized rats than in the control group. Melatonin administration (4 mg kg(-1) i.p. either before ischemia or reperfusion) to Px and sham-operated rats significantly reduced the MDA values and returned them to the control values. Morphological changes in the groups were similar to the MDA levels. Serum levels of blood urea nitrogen and creatine were unchanged. These results suggest that physiological and pharmacological melatonin concentrations are important for the reduction of I/R-induced damage. We also demonstrated that melatonin, even when administrated just before reperfusion, had a protective effect on I/R injury. It would seem valuable to test melatonin in clinical trials for the prevention of possible I/R injury.en_US
dc.identifier.doi10.1007/s00240-003-0314-5
dc.identifier.endpage193en_US
dc.identifier.issn0300-5623
dc.identifier.issn1434-0879
dc.identifier.issue3en_US
dc.identifier.pmid12719947en_US
dc.identifier.startpage188en_US
dc.identifier.urihttps://doi.org/10.1007/s00240-003-0314-5
dc.identifier.urihttps://hdl.handle.net/11616/104512
dc.identifier.volume31en_US
dc.identifier.wosWOS:000184326600008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofUrological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectmelatoninen_US
dc.subjectpinealectomyen_US
dc.subjectrenal ischemia-reperfusionen_US
dc.titleThe protective effects of physiological and pharmacological concentrations of melatonin on renal ischemia-reperfusion injury in ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu