May viral load detected in saliva in the early stages of infection be a prognostic indicator in COVID-19 patients?

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dc.authoridAydin, Sukru/0000-0003-1105-3338
dc.authorwosidAydin, Sukru/AAM-3613-2021
dc.contributor.authorAydin, Sukru
dc.contributor.authorBenk, Isilay Gokce
dc.contributor.authorGeckil, Aysegul Altintop
dc.date.accessioned2024-08-04T20:59:56Z
dc.date.available2024-08-04T20:59:56Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: This study aimed to investigate the prognostic value of viral load detected in the saliva of COVID-19 patients in the early stage of infection. Study design: Oro-nasopharyngeal swab and saliva samples were collected from all patients simultaneously in the early stage of COVID-19. Viral loads were determined by extracting viral RNAs from saliva samples of patients whose ONP swabs were positive for SARS-CoV-2 by RT-qPCR. The demographic information, comorbidities, cycle threshold values, and one-month clinical courses were recorded and compared. Results: The patients' clinical course was evaluated for one month; 56 % of patients had mild disease, 26.4 % had moderate disease, 9.6 % had severe disease, and 8% had a critical/mortal disease. The average cycle threshold values of SARS-CoV-2 in saliva and ONP samples were measured as 22.28 and 24.19, respectively. Cycle threshold value of saliva was found to be significant in predicting disease severity (Eta coefficient 0.979). A statistically significant relationship was found between the disease's severity and the mean of ONP samples' Ctvalues (p < 0.05). Gender, age, body mass index, and co-morbidities were compared with the severity of the disease; no statistically significant difference was found. Conclusion: Viral load detected in saliva in the early period of COVID-19 infection may have a prognostic value in showing the disease's course in patients over 45-year-old. Saliva is an easily obtainable, reliable material for COVID-19 screening.en_US
dc.identifier.doi10.1016/j.jviromet.2021.114198
dc.identifier.issn0166-0934
dc.identifier.issn1879-0984
dc.identifier.pmid34044003en_US
dc.identifier.urihttps://doi.org/10.1016/j.jviromet.2021.114198
dc.identifier.urihttps://hdl.handle.net/11616/103668
dc.identifier.volume294en_US
dc.identifier.wosWOS:000661415300011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Virological Methodsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSARS-CoV-2en_US
dc.subjectViral loaden_US
dc.subjectSalivaen_US
dc.subjectPrognosisen_US
dc.titleMay viral load detected in saliva in the early stages of infection be a prognostic indicator in COVID-19 patients?en_US
dc.typeArticleen_US

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