Methionine sulfoxide reduction and the aging process
Yükleniyor...
Dosyalar
Tarih
2007
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Ann N Y Acad Sci.
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aging has been described for multicellular and asymmetri-cally dividing organisms, but the mechanisms are poorly understood. Ox-idation of proteins is considered to be one of the major factors that leadsto aging. Oxidative damage to proteins results in the oxidation of certainamino acid residues, among which oxidation of sulfur-containing aminoacids, methionine and cysteine, is notable because of the susceptibility ofthese residues to damage, and occurrence of repair mechanisms. Methio-nine sulfoxide reductases, MsrA and MsrB, are thioredoxin-dependentoxidoreductases that reduce oxidized forms of methionine, methioninesulfoxides, in a stereospecific manner. These enzymes are present in allcell types and have shown to be regulating life spans in mammals, insects,and yeast. Here, their roles in modulating yeast life span are discussed.
Açıklama
Ann N Y Acad Sci.
Anahtar Kelimeler
Aging, ROS, Methionine sulfoxide reductase, Anaerobic, Yeast life span
Kaynak
Ann N Y Acad Sci.
WoS Q Değeri
Scopus Q Değeri
Cilt
1100
Sayı
Künye
Koç, A., & Vadim, Gladyshev. (2007). Methionine Sulfoxide Reduction And The Aging Process . Ann N Y Acad Sci., (1100), 383–0.
