Lipid peroxidation and antioxidative enzyme activities in childhood epilepsy

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dc.authoridSozuer, Dilsad/0000-0002-6607-5860
dc.authorwosidTürkdoğan, Dilşad/HJZ-4584-2023
dc.contributor.authorTurkdogan, D
dc.contributor.authorToplan, S
dc.contributor.authorKarakoc, Y
dc.date.accessioned2024-08-04T20:59:51Z
dc.date.available2024-08-04T20:59:51Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study aimed to investigate the relationship among lipid peroxidation, subsequent activation of scavenger enzymes (superoxide dismutase and glutathione peroxidase), and the presence of structural abnormality in 52 epileptic children receiving monotherapy (medically responsive) or polytherapy (medically intractable). Plasma lipid peroxidation in epileptic patients with abnormal magnetic resonance imaging (MRI) findings significantly increased as compared with that of 16 healthy children (P<.05), whereas antioxidant enzymes were not significantly affected. Both medically controlled and intractable children with normal MRI had higher activities of superoxide dismutase than those of controls (P<.05). The activity of superoxide dismutase in epileptic patients with structural abnormality did not significantly change as compared with controls. Activity of glutathione peroxidase in all of the epileptic children was not significantly different from controls. The activity of antioxidant enzymes or plasma malonyldialdehyde levels did not correlate with duration of epilepsy, frequency of seizures (> one seizure per month or not), and the presence or localization (focal, multifocal, or generalized) of electroencephalographic or MRI abnormalities. Increased plasma lipid peroxidation may be causally related to the presence of structural abnormality rather than ongoing epileptic activity or therapy status.en_US
dc.identifier.doi10.1177/088307380201700904
dc.identifier.endpage676en_US
dc.identifier.issn0883-0738
dc.identifier.issue9en_US
dc.identifier.pmid12503643en_US
dc.identifier.startpage673en_US
dc.identifier.urihttps://doi.org/10.1177/088307380201700904
dc.identifier.urihttps://hdl.handle.net/11616/103595
dc.identifier.volume17en_US
dc.identifier.wosWOS:000179781400004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherB C Decker Incen_US
dc.relation.ispartofJournal of Child Neurologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGlutathione-Peroxidaseen_US
dc.subjectSuperoxide-Dismutaseen_US
dc.subjectRat-Brainen_US
dc.subjectChildrenen_US
dc.titleLipid peroxidation and antioxidative enzyme activities in childhood epilepsyen_US
dc.typeArticleen_US

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