The comparison of 24-hour urinary protein excretion and the urine protein creatinine ratio in obese and morbidly obese individuals
Küçük Resim Yok
Tarih
2025
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bayrakol Medical Publisher
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: Obesity is a major global health issue and a recognized risk factor for chronic kidney disease (CKD). Proteinuria, a key marker of renal function, is traditionally assessed via 24-hour urine collection, though this poses practical challenges. This study evaluated the correlation between spot urine protein-tocreatinine ratio (PCR) and 24-hour proteinuria in obese individuals, exploring the feasibility of using spot PCR as a simpler alternative. Materials and Methods: A total of 178 obese individuals (BMI >= 35) were included in this prospective study conducted between August 2015 and October 2017. Individuals with conditions potentially affecting renal function were excluded. Proteinuria was assessed through both 24-hour urine collection and spot urine PCR. Correlation analyses were performed using Pearson or Spearman tests based on data distribution. Results: The mean age of participants was 40.1 +/- 11.5 years, with 75.3% being female. Proteinuria levels showed a moderate but statistically significant correlation between spot urine PCR and 24-hour urine protein excretion (p = 0.003, r = 0.223). However, in the subgroup with spot urine proteinuria >= 0.2 g/day, the correlation was not statistically significant (p = 0.064). BMI and proteinuria were weakly correlated, with results approaching but not reaching statistical significance (p = 0.051, r(2) = 0.147). Discussion: Spot urine PCR demonstrates a moderate correlation with 24-hour urinary protein excretion and may serve as a practical screening tool for proteinuria in obese individuals. However, its reliability in cases of higher proteinuria requires further investigation with larger sample sizes.
Açıklama
Anahtar Kelimeler
obesity, chronic kidney disease, protein-to-creatinine ratio
Kaynak
Annals of Clinical and Analytical Medicine
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
16
Sayı
9
