Evaluation of Oxidant Injury Induced by Irradiation in Brain Tissues of Rats of Different Ages

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dc.authoridBatcioglu, Kadir/0000-0001-6663-2287
dc.authoridUyumlu, Ayşe Burçin/0000-0001-9517-9274
dc.authoridYucel, Neslihan/0000-0001-5845-2614
dc.authorwosidErkal, Haldun Sukru/AAC-8209-2019
dc.authorwosidBatcioglu, Kadir/Q-2424-2015
dc.authorwosidUyumlu, Ayşe Burçin/ABH-5573-2020
dc.authorwosidYucel, Neslihan/ABI-3412-2020
dc.contributor.authorUyumlu, Ayse Burcin
dc.contributor.authorErkal, Haldun Suekrue
dc.contributor.authorBatcioglu, Kadir
dc.contributor.authorSerin, Meltem
dc.contributor.authorYucel, Neslihan
dc.date.accessioned2024-08-04T20:58:45Z
dc.date.available2024-08-04T20:58:45Z
dc.date.issued2009
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives: We aimed to evaluate the age-related changes of oxidative injury in the brain tissues of rats produced by radiotherapy that is widely used on cancer treatment. Study Design: Fifty-five male Wistar albino rats [ages of rats were 1, 4, 12 weeks (n=10) and 1 year (n=5)] were divided into four groups. Irradiation were performed on a Cobalt-60 unit using a single fraction of 8 Gy. The brain tissues were homogenized and divided into two portions. One portion was used for the measurement of the malondialdehyde (MDA). The other portion was used for the measurement of the protein concentration, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx) enzyme activities. Results: The SOD activity decreased significantly in 1-week-old rats (p<0.05). The decreases in GSHPx and CAT activities were more obvious in 1-week and 1-year-old rats than that in others. No significant changes were observed in adolescent and adult rats. The MDA levels of all groups increased. The highest MDA levels were seen in 1-year-old rats (p<0.05). Conclusion: Ionizing radiation used in radiotherapy affected antioxidant systems and increased MDA levels. These changes were more in the 1-week and 1-year-old rats than in others. This can be due to incomplete development of many systems in newborn rats and the loss of physiological capacities associated with aging in 1 -year-old rats.en_US
dc.identifier.endpage243en_US
dc.identifier.issn1301-3149
dc.identifier.issue3en_US
dc.identifier.startpage237en_US
dc.identifier.urihttps://hdl.handle.net/11616/103123
dc.identifier.volume26en_US
dc.identifier.wosWOS:000271437100009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAves Yayincilik, Ibrahim Karaen_US
dc.relation.ispartofTrakya Universitesi Tip Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRadiotherapyen_US
dc.subjectagingen_US
dc.subjectoxidant injuryen_US
dc.subjectbrainen_US
dc.subjectfree radicalsen_US
dc.titleEvaluation of Oxidant Injury Induced by Irradiation in Brain Tissues of Rats of Different Agesen_US
dc.typeArticleen_US

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