Diagnostic Value of Adenosine Deaminase Level for the Differential Diagnosis of Tuberculosis and Malignancy in Exudative Lymphocytic Pleurisy

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dc.authoridaltınsoy, bülent/0000-0002-2481-0978
dc.authoridYalçınsoy, Murat/0000-0003-3407-7359;
dc.authorwosidaltınsoy, bülent/HJP-4237-2023
dc.authorwosidGungor, Sinem/AAZ-7783-2021
dc.authorwosidÜnver, Edhem/ABF-8926-2020
dc.authorwosidYalçınsoy, Murat/ABI-1421-2020
dc.authorwosidGungor, Sinem/AAR-6777-2021
dc.contributor.authorAltinsoy, Bulent
dc.contributor.authorYalcinsoy, Murat
dc.contributor.authorUnver, Edhem
dc.contributor.authorGungor, Sinem
dc.contributor.authorMihmanli, Aydanur
dc.contributor.authorAkkaya, Esen
dc.date.accessioned2024-08-04T20:57:41Z
dc.date.available2024-08-04T20:57:41Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To evaluate the diagnostic performance of adenosine deaminase (ADA) levels in patients with exudative lymphocytic pleurisy for the differential diagnosis of tuberculous pleurisy (TBP) and malignant pleural effusion (MPE). Methods: Data on patients with exudative lymphocytic pleurisy were retrospectively analyzed. The study population comprised 54 patients. Thirty-seven were diagnosed with TBP and 17 were diagnosed with MPE. Results: Significant differences were determined in terms of age and ADA, total protein, albumin, and LDH levels between the TBP and MPE groups. The optimal cut-off value of ADA levels was 35.1 U/L for diagnosing TBP. Sensitivity and specificity were 92% and 100%, respectively. Logistic regression analysis was performed to assess independent variables associated with TBP. Independent predictive factors in the model were ADA (OR: 1.21, 95% CI: 1.06-1.39, p=0.006)], and (OR: 0.92, 95% CI: 0.84-1.00, p=0.052)]. The AUC value by the regression equation was 0.979 (p<0.001). When patients were categorized according to age (<50 ve >= 50), two different cut-off values (> 13.51 and > 35.1) for each age range were found in all, but one, TBP patients. Conclusion: ADA levels are useful for the diagnosis of TBP in cases where pleural biopsy cannot be performed or that are inconclusive in making a diagnosis of TBP. In this group, reducing the conventional cut-off value and/or performing an age-based approach seems to improve the diagnostic performance of ADA levels.en_US
dc.identifier.doi10.5152/imj.2016.34735
dc.identifier.endpage63en_US
dc.identifier.issn1304-8503
dc.identifier.issn2148-094X
dc.identifier.issue2en_US
dc.identifier.startpage59en_US
dc.identifier.urihttps://doi.org/10.5152/imj.2016.34735
dc.identifier.urihttps://hdl.handle.net/11616/102833
dc.identifier.volume17en_US
dc.identifier.wosWOS:000382877000004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherAvesen_US
dc.relation.ispartofIstanbul Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdenosine deaminaseen_US
dc.subjectmalignancyen_US
dc.subjecttuberculosisen_US
dc.subjectpleurisyen_US
dc.titleDiagnostic Value of Adenosine Deaminase Level for the Differential Diagnosis of Tuberculosis and Malignancy in Exudative Lymphocytic Pleurisyen_US
dc.typeArticleen_US

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