Clinicopathologic and Prognostic Differences between Three Different Age Groups (Child/Adolescent, Young Adults, and Adults) of Colorectal Cancer Patients: A Multicentre Study

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dc.authoridUysal, Mukremin/0000-0002-8524-0665
dc.authoridKaplan, Muhammet Ali/0000-0003-0882-0524
dc.authoridaksoy, asude/0000-0002-5609-9658
dc.authoridSAKIN, Abdullah/0000-0003-2538-8569
dc.authorwosidGeredeli, Caglayan/AAN-4122-2020
dc.authorwosidGumus, Mahmut/HTO-4176-2023
dc.authorwosidUysal, Mukremin/B-8956-2014
dc.contributor.authorKaplan, Muhammet Ali
dc.contributor.authorOzaydin, Sukru
dc.contributor.authorYerlikaya, Halis
dc.contributor.authorKaraagac, Mustafa
dc.contributor.authorGumus, Mahmut
dc.contributor.authorCil, Timucin
dc.contributor.authorArslan, Ulku Yalcintas
dc.date.accessioned2024-08-04T20:57:26Z
dc.date.available2024-08-04T20:57:26Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Colorectal cancer (CRC) is a rare disease amongst children and adolescents. Previous studies have reported a number of differences between children/adolescents, young adults, and adult patients with CRC. However, none of these studies compared these age groups according to their clinicopathologic and prognostic characteristics. In the current study, we compare these three age groups. Methods:A total of 173 (1.1% of 15,654 patients) young CRC patients (<= 25 years) were included in the study. As a control group, 237 adult CRC patients (>25 years) were also included. Patients were divided into three age groups: child/adolescent (10-19 years), young adult (20-25 years), and adult (>25 years). Results: Statistical differences amongst the three groups in terms of gender (p = 0.446), family history (p = 0.578), symptoms of presentation (p = 0.306), and interval between initiation of symptoms and diagnosis (p = 0.710) could not be demonstrated. Whilst abdominal pain (p < 0.001) and vomiting (p = 0.002) were less common in young adults than in other groups, rectal bleeding and changes in bowel habits were relatively less common in adolescents than in other groups. Rectal localisation (p = 0.035), mucinous adenocarcinoma (p < 0.001), and a poorly differentiated histologic subtype (p < 0.001) were less common in the adult group than in other groups. The percentage of patients with metastasis and sites of metastasis (e.g., peritoneum and lung) differed between groups. The median overall survival was 32.6 months in the adolescent group, 57.8 months in the young adult group and was not reached in the adult group (p = 0.022). The median event-free survival of the adolescent, young adult, and adult groups was 29.0, 29.9, and 61.6 months, respectively (p = 0.003). Conclusions: CRC patients of different age groups present different clinicopathologic and prognostic characteristics. Clinicians should be aware of and manage the disease according to these differences.en_US
dc.identifier.doi10.1159/000502120
dc.identifier.endpage522en_US
dc.identifier.issn2296-5270
dc.identifier.issn2296-5262
dc.identifier.issue10en_US
dc.identifier.pmid31437835en_US
dc.identifier.startpage516en_US
dc.identifier.urihttps://doi.org/10.1159/000502120
dc.identifier.urihttps://hdl.handle.net/11616/102609
dc.identifier.volume42en_US
dc.identifier.wosWOS:000489996700003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofOncology Research and Treatmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColorectal canceren_US
dc.subjectYoungen_US
dc.subjectAdolescenten_US
dc.subjectChilden_US
dc.titleClinicopathologic and Prognostic Differences between Three Different Age Groups (Child/Adolescent, Young Adults, and Adults) of Colorectal Cancer Patients: A Multicentre Studyen_US
dc.typeArticleen_US

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