The effects of N acetylcysteine on pulmonary functions in patients undergoing on pump coronary artery surgery a double blind placebo controlled study

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dc.authorid8752en_US
dc.authorid239816en_US
dc.authorid239816en_US
dc.authorid110112en_US
dc.authorid9608en_US
dc.contributor.authorErdil, Nevzat
dc.contributor.authorEroğlu, Tamer
dc.contributor.authorAkça, Barış
dc.contributor.authorDişli, Olcay Murat
dc.contributor.authorYetkin, Özkan
dc.contributor.authorÇolak, Mehmet Cengiz
dc.contributor.authorErdil, Feray Akgül
dc.contributor.authorBattaloğlu, Bektaş
dc.date.accessioned2017-07-15T12:41:55Z
dc.date.available2017-07-15T12:41:55Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.descriptionEuropean Review for Medical and Pharmacological Sciencesen_US
dc.description.abstractAbstract. – OBJECTIVE: To investigate the effects of N-acetylcysteine (NAC) on pulmonary function tests and arterial blood gases in patients undergoing on-pump coronary artery surgery. PATIENTS AND METHODS: The effect of NAC was assessed within the scope of a prospective, single center, double-blind, placebo-controlled, parallel group study. Eighty-two patients undergoing coronary artery bypass grafting were randomized into two groups to receive either placebo (group 1, n = 40) or NAC (group 2, n=42). Both the NAC group and the placebo-receiving control group also included a COPD subgroup consisting of patients with an FEV1/FVC ratio of < 0.7 and an FEV1 value of 50- 80%. Pulmonary function tests were performed preoperatively and on postoperative day 60. RESULTS: Both groups were similar with respect to age, gender, preoperative risk factors, ejection fraction (EF), mean cross-clamp time, ventilation time, intensive care unit (ICU) stay, atrial fibrillation (AF) and hospital stay (p > 0.05). Postoperative FVC and FEV1 values in group 1 and the postoperative FEV1, FEV1/FVC and FEF 25-75 values in group 2 were lower in comparison to their preoperative values. However, in both group 1 and 2, the decreases observed in these parameters were not statistically significant (p > 0.05). In the COPD subgroup of group 1, a postoperative decrease was observed in the FEV1 and FEF25-75 values, with the FEV1 decreasing by 4.55%, and the FEF25-75 decreasing by 4.2% (p < 0.05). In the COPD subgroup of group 2, no significant decrease was observed in the pulmonary function test values (p > 0.05).en_US
dc.identifier.citationERDİL, N., EROĞLU, T., AKÇA, B., DİŞLİ, O. M., YETKİN, Ö., ÇOLAK, M. C., … BATTALOĞLU, B. (2016). The effects of N acetylcysteine on pulmonary functions in patients undergoing on pump coronary artery surgery a double blind placebo controlled study. Eur Rev Med Pharmacol Sci, 0–0.en_US
dc.identifier.endpage0en_US
dc.identifier.issue0en_US
dc.identifier.startpage0en_US
dc.identifier.urihttp://www.europeanreview.org/wp/wp-content/uploads/180-187.pdf
dc.identifier.urihttps://hdl.handle.net/11616/7398
dc.identifier.volume0en_US
dc.language.isoenen_US
dc.publisherEur rev med pharmacol scien_US
dc.relation.ispartofEur rev med pharmacol scien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectN-Acetylcysteineen_US
dc.subjectPulmonary function testen_US
dc.subjectBypass surgeryen_US
dc.subjectCoronary arteryen_US
dc.titleThe effects of N acetylcysteine on pulmonary functions in patients undergoing on pump coronary artery surgery a double blind placebo controlled studyen_US
dc.typeArticleen_US

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