Serum IL-33 level and IL-33 gene polymorphisms in Behcet's disease

Basit Öğe Kaydı
dc.authoridIlhan, Nevin/0000-0002-0208-8929
dc.authoridDemir, Caner Feyzi/0000-0002-2861-2418
dc.authorwosidIlhan, Nevin/J-5761-2017
dc.authorwosidDemir, Caner Feyzi/AAO-2045-2021
dc.contributor.authorKoca, Suleyman Serdar
dc.contributor.authorKara, Murat
dc.contributor.authorDeniz, Firat
dc.contributor.authorOzgen, Metin
dc.contributor.authorDemir, Caner Feyzi
dc.contributor.authorIlhan, Nevin
dc.contributor.authorIsik, Ahmet
dc.date.accessioned2024-08-04T21:01:08Z
dc.date.available2024-08-04T21:01:08Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBeh double dagger et's disease (BD) is a chronic inflammatory disease. Increased productions of cytokines including interleukin (IL)-1 beta and IL-18 are documented, and IL-1 alpha and beta gene polymorphisms are associated with susceptibility to the disease. IL-33 is a recently discovered member of IL-1 cytokine family. The aim of the study was to detect serum IL-33 level and IL-33 gene polymorphisms in a cohort of BD. Unrelated 117 patients with BD and 149 healthy controls (HC) were enrolled. Serum IL-33 levels were analyzed by enzyme-linked immunosorbent assay method. DNA samples were harvested using an appropriate commercial DNA isolation kit. Four single nucleotide polymorphisms of IL-33 gene (rs7044343, rs1157505, rs11792633 and rs1929992) were genotyped using the appropriate commercial primer/probe sets on real-time PCR. Serum IL-33 level was not significantly different in the BD and HC groups (p > 0.05). However, its level was lower in the active BD patients compared to the inactive ones and HC group (p = 0.044 and p = 0.037, respectively). There was no significant difference in terms of the genotypic and allelic distributions of rs1157505 and rs1929992 polymorphisms (p > 0.05 for all). However, the TT variants of rs7044343 and rs11792633 polymorphisms were very rare, and the T allele frequencies of these polymorphisms were lower, in the BD group compared to the HC group (p < 0.0001 for all). The rs7044343 and rs11792633 variants of IL-33 gene are associated with the decreased risk of BD in our cohort. Therefore, it may be concluded that IL-33 acts a protective role on the pathogenesis of BD.en_US
dc.identifier.doi10.1007/s00296-014-3111-2
dc.identifier.endpage477en_US
dc.identifier.issn0172-8172
dc.identifier.issn1437-160X
dc.identifier.issue3en_US
dc.identifier.pmid25119832en_US
dc.identifier.startpage471en_US
dc.identifier.urihttps://doi.org/10.1007/s00296-014-3111-2
dc.identifier.urihttps://hdl.handle.net/11616/104111
dc.identifier.volume35en_US
dc.identifier.wosWOS:000350035600009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofRheumatology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBehcet's diseaseen_US
dc.subjectIL-33en_US
dc.subjectPolymorphismsen_US
dc.titleSerum IL-33 level and IL-33 gene polymorphisms in Behcet's diseaseen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu