Protective effect of aminoguanidine against oxidative stress in an experimental peritoneal adhesion model in rats
Yükleniyor...
Dosyalar
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Cell Biochem Funct.
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Postoperative intraperitoneal adhesion formation is a major cause of intestinal obstruction, pain and infertility. This experimental
study was designed to evaluate the degree of adhesion formation and peritoneal tissue levels of malondialdehyde
(MDA), reduced glutathione (GSH) and total nitrite and nitrate (NO) and the effect of aminoguanidine (AG) on these metabolite
values after postoperative intraperitoneal adhesion formation in rats. A total of 21 adult male Wistar albino rats were
randomly divided into three groups. Control rats were untreated; the AG group received AG 200 mg kg 1 i.p. for 10 consecutive
days intraperitoneally after surgery. The sham group was given 0.9% NaCl. The rats were killed on postoperative
day 10. The peritoneal tissues were harvested to determine the tissue levels of MDA, GSH, and NO activity. For light microscopic
evaluation, the cecum was removed. Adhesion formation scores in the AG group were significantly lower than those
of the control and sham groups ( p < 0.017, p < 0.026 respectively). In the AG-treated rats, tissue levels of MDA and NO
were significantly lower than in the control group ( p < 0.017). The levels of GSH in aminoguanidine-treated rats were significantly
higher than those of the control group ( p < 0.01). The severity of the inflammation was more prominent in the
control group compared with the AG-injected rats. The results demonstrate that in this experimental model, intraperitoneal
administration of aminoguanidine decreases the incidence and extent of peritoneal adhesions and causes a decrease in MDA
and NO and an increase in GSH values.
Açıklama
Anahtar Kelimeler
Aminoguanidine, Malondialdehyde, Nitric oxide, Reduced glutathione, Adhesion
Kaynak
Cell Biochem Funct.
WoS Q Değeri
Scopus Q Değeri
Cilt
24
Sayı
Künye
Ara, C. Bay Karabulut, A. Kırımlıoğlu, S. H. Yılmaz, M. Kırımlıoğlu, V. Yılmaz, S. (2006). Protective effect of aminoguanidine against oxidative stress in an experimental peritoneal adhesion model in rats. Cell Biochem Funct. 24: 443–448.
