XPD and XRCC1 gene polymorphism in patients with normal and abnormal cervical cytology by pap smear

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dc.authorid101949en_US
dc.contributor.authorYılmaz, E.
dc.contributor.authorÇelik, Ö.
dc.contributor.authorTürkçüoğlu, I.
dc.contributor.authorŞimşek, Y.
dc.contributor.authorKaraer, A.
dc.contributor.authorOtlu, Barış
dc.contributor.authorGülbay, G.
dc.contributor.authorYeşilada, E.
dc.date.accessioned2017-07-15T06:24:49Z
dc.date.available2017-07-15T06:24:49Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe purpose of the present study was to identify the role of abnormalities in DNA repair pathways by measuring the XPD and XRCC1 gene polymorphisms. MATERIALS AND METHODS: Thirty-five patients with abnormal cervical cytology (study group) and 10 women with normal cytology (control group) were included in the study. The polymorphisms of XRCC1 Arg194Trp, XRCC1 Arg399Gln and XPD Lys751Gln genes were investigated from the blood samples. RESULTS: There was no statistically significant difference in allele frequencies of XPD gene among the groups (p = 0.097), while XRCC1R399Q gene polymorphism was strikingly more frequent in the study group than that of control cases (p = 0.029). The prevalence of XRCC1R194W gene polymorphism on the other hand, was similar between the groups (p = 0.579). CONCLUSIONS: Patients with abnormal and normal cervical cytology have similar XPD gene polymorphism. However, the frequency of gene polymorphism in XRCC1 Arg 399 Gln codon was significantly higher in abnormal cervical cytology group.en_US
dc.identifier.citationYılmaz, E. Çelik, Ö. Türkçüoğlu, I. Şimşek, Y. Karaer, A. Otlu, B. Gülbay, G. Yeşilada, E. (2012). XPD and XRCC1 gene polymorphism in patients with normal and abnormal cervical cytology by pap smear. European Review for Medical and Pharmacological Sciences. 16;1713-1718.en_US
dc.identifier.endpage1718en_US
dc.identifier.issn1128-3602
dc.identifier.startpage1713en_US
dc.identifier.urihttps://hdl.handle.net/11616/7377
dc.identifier.volume116en_US
dc.language.isoenen_US
dc.publisherEuropean Review for Medical and Pharmacological Sciencesen_US
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciencesen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCervical intraepithelial neoplasiaen_US
dc.subjectPolymorphismen_US
dc.subjectCervixen_US
dc.subjectDNA repairen_US
dc.titleXPD and XRCC1 gene polymorphism in patients with normal and abnormal cervical cytology by pap smearen_US
dc.typeArticleen_US

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