Association between fragmented QRS complexes and left ventricular dysfunction in healthy smokers

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dc.authoridTaşolar, Hakan/0000-0002-1249-7240;
dc.authorwosidKaya, Ahmet/AAU-2164-2021
dc.authorwosidBayramoğlu, Adil/ABI-3122-2020
dc.authorwosidTaşolar, Hakan/ABG-4466-2020
dc.authorwosidBayramoğlu, Adil/ABF-2802-2020
dc.contributor.authorBayramoglu, Adil
dc.contributor.authorTasolar, Hakan
dc.contributor.authorBektas, Osman
dc.contributor.authorKaya, Ahmet
dc.contributor.authorGunaydin, Zeki Yuksel
dc.date.accessioned2024-08-04T20:57:12Z
dc.date.available2024-08-04T20:57:12Z
dc.date.issued2019
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: Smoking is a known risk factor for cardiovascular diseases and may cause myocardial damage independently of coronary artery disease. Fragmented ORS (f(lRS) is an important marker of myocardial fibrosis, while speckle-tracking echocardiography is a method used to show subclinical left ventricle dysfunction. Methods: Our study included 230 healthy individuals aged 18-40 years. The patients included were separated into two groups: those smokers (n = 130) and nonsmokers (n = 100). After that healthy smokers group were divided into two groups: those with fQRS (n = 24) and those without (n = 106). In both groups, the arithmetic mean of three images was used to obtain the left ventricle global longitudinal strain (LV-GLS). The E/SRe ratio was also calculated and analyzed. Results: There were significant differences between the smokers and non-smokers in terms of, E/SRe (55.7 +/- 17.9 vs 50.3 +/- 14.8; = 0.015), LV-GLS (23.1 +/- 1.9 vs 24.0 +/- 1.7; P = 0.001), and fQRS (18.5% vs 6%; P = 0.005). As a result of subgroup analysis, pack-year history was higher in the fQRS positive group (16.7 +/- 3.7 vs 11.2 +/- 3.7, P < 0.001). While a negative correlation was observed between pack-year history and LV-GLS (r =-0.678, P < 0.001), there was a positive correlation between pack-year history and E/SRe (r = 0.730, P < 0.001). Conclusion: In conclusion, our study demonstrated that fQRS is a parameter that can be used to determine left ventricle subclinical systolic and diastolic dysfunction in smokers, and that left ventricle dysfunction is related to the duration and intensity of smoking.en_US
dc.identifier.doi10.1111/echo.14223
dc.identifier.endpage296en_US
dc.identifier.issn0742-2822
dc.identifier.issn1540-8175
dc.identifier.issue2en_US
dc.identifier.pmid30561037en_US
dc.identifier.startpage292en_US
dc.identifier.urihttps://doi.org/10.1111/echo.14223
dc.identifier.urihttps://hdl.handle.net/11616/102428
dc.identifier.volume36en_US
dc.identifier.wosWOS:000458874600011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEchocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniquesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectfragmented QRSen_US
dc.subjectsmokingen_US
dc.subjectspeckle tracking echocardiographyen_US
dc.titleAssociation between fragmented QRS complexes and left ventricular dysfunction in healthy smokersen_US
dc.typeArticleen_US

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