Comparison of the simultaneous conjunctiva and oropharynx-nasopharynx swab results in patients applying to the SARS-CoV-2 outpatient clinic for the first time

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dc.authoridGündüz, Ayten/0000-0003-2031-9978
dc.authoridFirat, Murat/0000-0001-6040-9332
dc.authorwosidGündüz, Ayten/HKO-6509-2023
dc.contributor.authorGunduz, Ayten
dc.contributor.authorFirat, Murat
dc.contributor.authorTurkoglu, Gamze
dc.date.accessioned2024-08-04T20:57:29Z
dc.date.available2024-08-04T20:57:29Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim is to comparatively evaluate the results of simultaneous conjunctiva and oropharynx-nasopharynx (ONP) swabs in patients who had presented to the outpatient department with a suspicion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). An ONP sample was obtained following bilateral conjunctiva swabs in 85 subjects with a contact history or symptoms but unknown SARS-CoV-2 status and with no ocular symptoms or findings. The results were evaluated according to the patient's symptoms and how the swab was taken. The conjunctiva swab was positive in 29 (34.1%) cases and the ONP swab in 20 (23.5%) cases. Both methods produced positive results in 11 (14.1%) cases. The mean cycle threshold (C-t) value was 30.15 +/- 3.41 in symptomatic cases and 33.62 +/- 1.76 in asymptomatic cases (p = .008). The mean C-t value was 24.37 +/- 3.48 when only the ONP swab was positive and 31.22 +/- 1.99 when only the conjunctiva swab was positive. In cases that were positive by both methods, the mean C-t value was 25.21 +/- 4.94 for the ONP swab and 30.29 +/- 5.05 for the conjunctiva swab. We found higher SARS-CoV-2 detection rates with the conjunctiva swab than the ONP swab in cases with unknown SARS-CoV-2 status in the early period. In addition, the conjunctival viral load seemed to be higher in symptomatic cases than in asymptomatic cases. We, therefore, believe a conjunctiva swab could be an alternative method to detect SARS-CoV-2 at the time of the first presentation to the outpatient department.en_US
dc.description.sponsorshipBiyoeksen Ar-Ge Tekn. Ltd.en_US
dc.description.sponsorshipBiyoeksen Ar-Ge Tekn. Ltd., Grant/Award Number: their RT-PCR kits donated for our use utilizeden_US
dc.identifier.doi10.1002/jmv.26981
dc.identifier.endpage4522en_US
dc.identifier.issn0146-6615
dc.identifier.issn1096-9071
dc.identifier.issue7en_US
dc.identifier.pmid33783859en_US
dc.identifier.startpage4516en_US
dc.identifier.urihttps://doi.org/10.1002/jmv.26981
dc.identifier.urihttps://hdl.handle.net/11616/102675
dc.identifier.volume93en_US
dc.identifier.wosWOS:000646454400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Medical Virologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectconjunctival swaben_US
dc.subjectCOVID-19en_US
dc.subjectnasopharyngeal swaben_US
dc.subjectoropharyngeal swaben_US
dc.subjectSARS-CoV-2en_US
dc.subjecttearsen_US
dc.titleComparison of the simultaneous conjunctiva and oropharynx-nasopharynx swab results in patients applying to the SARS-CoV-2 outpatient clinic for the first timeen_US
dc.typeArticleen_US

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