The effect of caffeic acid phenethyl ester CAPE against cholestatic liver injury in rats

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dc.contributor.authorÇoban, Sacid
dc.contributor.authorYıldız, Fahrettin
dc.contributor.authorAlpaslan, Terzi
dc.contributor.authorAl, Behcet
dc.contributor.authorÖzgör, Dinçer
dc.contributor.authorAra, Cengiz
dc.contributor.authorAra, Cengiz
dc.contributor.authorPolat, Alaadin
dc.contributor.authorEsrefoğlu, Mukaddes
dc.date.accessioned2018-02-07T13:28:17Z
dc.date.available2018-02-07T13:28:17Z
dc.date.issued2010
dc.departmentİnönü Üniversitesien_US
dc.descriptionJournal of Surgical Research 159, 674–679 (2010)en_US
dc.description.abstractObjectives. Caffeic acid phenethyl ester (CAPE) has been subjected to considerable investigations that have revealed its antioxidant and anti-inflammatory activities in different conditions. But there is not a previous investigation about its effect on cholestatic liver injury. The aim of this study was to investigate the effect of CAPE in rat liver against cholestatic liver injury induced by bile duct ligation. Methods. Swiss-albino rats were recruited in the study as follows; Group 1 rats subjected to simple laparotomy known as the sham group; Group 2 rats subjected to bile duct ligation (BDL); Group 3 bile duct ligated rats treated with CAPE. The third group received CAPE (10 mmol/kg) intraperitoneally daily throughout 14 d. Results. Data showed a decrease in g glutamyl transferase (GGT), aspartate aminotransferase (AST), and alanine aminotransferase levels (ALT) of the CAPE treated rats, compared with BDL group (P < 0.001, P < 0.01, and P < 0.02, respectively). In the CAPE treated rats, tissue levels of malondialdehyde (MDA) and myeloperoxidase (MPO) were significantly lower than that of the BDL group (P < 0.001). The levels of glutathione (GSH) in CAPE treated rats were significantly higher than that of BDL group (P < 0.001). In CAPE treated group, the levels of interleukin1alpha (IL-1a) and interleukin-6 (IL-6) were signifi- cantly lower than that of BDL group (P < 0.03, P < 0.02, respectively). Administration of CAPE in the rats with biliary obstruction resulted in inhibition of necro-inflammation. Conclusion. These results suggest that treatment of CAPE maintains antioxidant defenses, reduces oxidative liver injury, cytokine damage, and necroinflammation in bile duct ligated rats. Thus, CAPE seems to be a promising agent for the attenuation of cholestatic liver injury. 2010 Elsevier Inc. All rights reserved.en_US
dc.identifier.citationÇoban, S. A., Yıldız, F., Terzi, A., Al, B., Özgör, D., Ara, C., … Eşrefoğlu, M. (2010). The Effect Of Caffeic Acid Phenethyl Ester Cape Against Cholestatic Liver İnjury İn Rats . J Surg Res, 0–0.en_US
dc.identifier.endpage0en_US
dc.identifier.issue0en_US
dc.identifier.startpage0en_US
dc.identifier.urihttps://ac.els-cdn.com/S0022480408006793/1-s2.0-S0022480408006793-main.pdf?_tid=a142829e-0c05-11e8-a6b1-00000aacb35f&acdnat=1518008076_147f990ee631a2d88b8f33b18348c03f
dc.identifier.urihttps://hdl.handle.net/11616/8054
dc.identifier.volume0en_US
dc.language.isoenen_US
dc.publisherJ Surg Res, 0–0.en_US
dc.relation.ispartofJ Surg Res, 0–0.en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCaffeic acid phenethyl ester (CAPE)en_US
dc.subjectBile duct ligationen_US
dc.subjectCholestatic liver injuryen_US
dc.titleThe effect of caffeic acid phenethyl ester CAPE against cholestatic liver injury in ratsen_US
dc.typeArticleen_US

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