The effect of ethyl pyruvate on oxidative stress in intestine and bacterial translocation after thermal injury

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dc.authorid116537en_US
dc.contributor.authorKarabeyoğlu, Melih
dc.contributor.authorÜnal, Bülent
dc.contributor.authorBozkurt, Betül
dc.contributor.authorDolapçı, İştar
dc.contributor.authorBilgihan, Ayşe
dc.contributor.authorKarabeyoğlu, Işıl
dc.contributor.authorCengiz, Ömer
dc.date.accessioned2017-08-14T10:31:50Z
dc.date.available2017-08-14T10:31:50Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. Thermal injury causes a breakdown in the intestinal mucosal barrier due to ischemia reperfusion injury, which can induce bacterial translocation (BT), sepsis, and multiple organ failure in burn patients. The aim of this study was to investigate the effect of ethyl pyruvate (EP) on intestinal oxidant damage and BT in burn injury. Materials and methods. Thirty-two rats were randomly divided into four groups. The sham group was exposed to 21°C water and injected intraperitoneal with saline (1 mL/100 g). The sham EP group received EP (40 mg/kg) intraperitoneally 6 h after the sham procedure. The burn group was exposed to thermal injury and given intraperitoneal saline injection (1 mL/100 g). The burn EP group received EP (40 mg/kg) intraperitoneally 6 h after thermal injury. Twenty-four hours later, tissue samples were obtained from mesenteric lymph nodes, spleen, and liver for microbiological analysis and ileum samples were harvested for biochemical analysis. Results. Thermal injury caused severe BT in burn group. EP supplementation decreased BT in mesenteric lymph nodes and spleen in the burn EP group compared with the burn group (P < 0.05). Also, burn caused BT in liver, but this finding was not statistically signifi- cant among all groups. Thermal injury caused a statistically significant increase in malondialdehyde and myeloperoxidase levels, and EP prevented this effects in the burn EP group compared with the burn group (P < 0.05). Conclusion. Our data suggested that EP can inhibit the BT and myeloperoxidase and malondialdehyde production in intestine following thermal injury, suggesting anti-inflammatory and anti-oxidant properties of EP.en_US
dc.identifier.citationKarabeyoğlu, M. Ünal, B. Bozkurt, B. Dolapçı, İ. Bilgihan, A. Karabeyoğlu, I. Cengiz, Ö. (2008). The effect of ethyl pyruvate on oxidative stress in intestine and bacterial translocation after thermal injury. J Surg Res. 144; 59-63.en_US
dc.identifier.doi10.1016/j.jss.2007.02.050en_US
dc.identifier.endpage63en_US
dc.identifier.startpage59en_US
dc.identifier.urihttps://hdl.handle.net/11616/7558
dc.identifier.volume144en_US
dc.language.isoenen_US
dc.publisherJ Surg Resen_US
dc.relation.ispartofJ Surg Resen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectİntestinal mucosal barrieren_US
dc.subjectThermal injuryen_US
dc.subjectEthyl pyruvateen_US
dc.subjectBacterial translocationen_US
dc.titleThe effect of ethyl pyruvate on oxidative stress in intestine and bacterial translocation after thermal injuryen_US
dc.typeArticleen_US

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