The effect of nimodipine and prednisolone on traumatic facial nerve injury treatment

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dc.authoridKeleş, Erol/0000-0003-4443-6714
dc.authoridYALCIN, SINASI/0000-0002-6528-9234
dc.authoridAKPOLAT, Nusret/0000-0002-9138-2117
dc.authoridKARLIDAG, turgut/0000-0003-2748-7309
dc.authoridKaygusuz, İrfan/0000-0002-5237-2362
dc.authorwosidKeleş, Erol/W-7207-2018
dc.authorwosidYALCIN, SINASI/W-7128-2018
dc.authorwosidAKPOLAT, Nusret/ABF-6986-2020
dc.authorwosidKARLIDAG, turgut/W-7266-2018
dc.authorwosidKaygusuz, İrfan/W-1486-2018
dc.contributor.authorDolen, Tolga
dc.contributor.authorKaygusuz, Irfan
dc.contributor.authorAkpolat, Nusret
dc.contributor.authorAlpay, Hayrettin Cengiz
dc.contributor.authorKeles, Erol
dc.contributor.authorKarlidag, Turgut
dc.contributor.authorYalcin, Sinasi
dc.date.accessioned2024-08-04T21:01:24Z
dc.date.available2024-08-04T21:01:24Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To investigate the histopathological effect of nimodipine and prednisolone treatment on an animal model with peripheral facial nerve paralysis generated by clamping. Methods: Twenty-eight New Zealand originated rabbits with facial nerve paralysis of the buccal branches generated by clamping were divided into four groups of seven each, administered with nimodipine, methylprednisolone and nimodipine-methylprednisolone combination throughout 21 days. The injured neural tissues were investigated histopathologically after treatment regarding perineural fibrosis, collagen degeneration, axonal degeneration, myelin degeneration, Schwann cell proliferation, normal myelin structure, and edema. The groups were compared with each other and with the control group. Results: Statistically significant difference was determined between nimodipine and control groups regarding increased number of collagen fibers, myelin degeneration, axonal degeneration and myelin structure; between nimodipine and methylprednisolone groups, and between nimodipine and nimodipine-methylprednisolone combination groups regarding edema (p< 0.05). Statistically significant data were also found between methylprednisolone and control groups in terms of increased number of collagen fibers, myelin degeneration, axonal degeneration and edema; between nimodipine-methylprednisolone combination and the control groups in terms of increased number of collagen fibers, myelin degeneration, axonal degeneration, normal myelin structure and edema (p< 0.05). Conclusion: Nimodipine and methylprednisolone both have positive effects on traumatic peripheral nerve paralysis with nerve integrity preserved whereas advantage of nimodipine over methylprednisolone cannot be suggested.en_US
dc.identifier.doi10.2399/jmu.2017001011
dc.identifier.endpage8en_US
dc.identifier.issn2149-7109
dc.identifier.issn2149-6498
dc.identifier.issue1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.2399/jmu.2017001011
dc.identifier.urihttps://hdl.handle.net/11616/104361
dc.identifier.volume7en_US
dc.identifier.wosWOS:000404729700002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherDeomed Publ, Istanbulen_US
dc.relation.ispartofEnt Updatesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFacial nerve paralysisen_US
dc.subjectnimodipineen_US
dc.subjectmethylprednisoloneen_US
dc.titleThe effect of nimodipine and prednisolone on traumatic facial nerve injury treatmenten_US
dc.typeArticleen_US

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