Effects of micronised purified flavonoid fraction on pain spermiogram and scrotal color doppler parameters in patients with painful varicocele
| dc.authorid | 113611 | en_US |
| dc.contributor.author | Kılıç, Süleyman | |
| dc.contributor.author | Güneş, Ali | |
| dc.contributor.author | İpek, Deniz | |
| dc.contributor.author | Dusak, Abdurrahim | |
| dc.contributor.author | Güneş, Gülsen | |
| dc.contributor.author | Balbay, Derya Mevlana | |
| dc.contributor.author | Baydinç, Can | |
| dc.date.accessioned | 2017-06-27T08:08:38Z | |
| dc.date.available | 2017-06-27T08:08:38Z | |
| dc.date.issued | 2005 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description.abstract | Purpose: Micronised purifi ed fl avonoid fraction (MPFF) is a phlebotropic drug improving venous tone, elasticity and lymphatic drainage, decreasing venous distensibility, venous emptying times, refl ux time of venous blood and capillary hyperpermeability, and having antioxidant activities. Since varicocele is a venous pathology, we evaluated the effects of MPFF on pain, spermiogram and color Doppler parameters in patients with painful varicocele. Material and Methods: Semen analyses and Doppler sonography were performed in 16 patients (aged 20–62 years, mean 31.2 8 10.9) before and after 1,000 mg/day MPFF treatment. Pain change was assessed with visual analogue scale scored between 0 and 10. Patient satisfaction with outcome and side effects were recorded. Results: Mean pain scores at 1, 3, and 6 months were 1.25 8 1.34, 0.25 8 0.68, and 0.12 8 0.34, respectively, all being signifi cantly lower (p ! 0.001 for each) than baseline (4.93 8 1.77). Mean score at 12 months (0.93 8 1.06) was still lower than baseline (p ! 0.001) but higher than at 6 months (p = 0.019). Respectively, 14 (87.5%) and 2 (12.5%) patients reported complete and very signifi cant resolution of pain at the 6th month. All patients were very satisfi ed with the outcome. While semen volume, total sperm count, sperm concentration and morphology did not change signifi cantly, motility increased signifi cantly (p = 0.009) due to decrease of grade 0 sperms (p = 0.006) and increase of grade 3 + 4 sperms (p ! 0.001). Refl ux time of left spermatic vein during the Valsalva maneuver decreased signifi cantly (p = 0.003). No signifi cant change occurred in refl ux time of the right spermatic vein. No side effect was recorded. Conclusions: Results of this preliminary study suggest the safety and effi cacy of MPFF in the treatment of varicocele-associated pain. However, no recommendation for the use of MPFF in the treatment of pain associated with varicocele can be made before these preliminary results are confi rmed by a randomized pla cebocontrolled trial. | en_US |
| dc.identifier.citation | Kılıç, S. Güneş, A. İpek, D. Dusak, A. Güneş, G. Balbay, D. M. Baydinç, C. (2005). Effects of micronised purified flavonoid fraction on pain spermiogram and scrotal color Doppler parameters in patients with painful varicocele . Urol Int, 74(2), 173–179. | en_US |
| dc.identifier.doi | 10.1159/000083290 | en_US |
| dc.identifier.endpage | 179 | en_US |
| dc.identifier.issue | 2 | en_US |
| dc.identifier.startpage | 173 | en_US |
| dc.identifier.uri | : https://www.researchgate.net/publication/7978466 | |
| dc.identifier.uri | https://hdl.handle.net/11616/7247 | |
| dc.identifier.volume | 74 | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Urol Int | en_US |
| dc.relation.ispartof | Urol Int | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Varicocele | en_US |
| dc.subject | Micronised purifi ed fl avonoid fraction | en_US |
| dc.subject | Pain | en_US |
| dc.subject | Spermiogram | en_US |
| dc.subject | Doppler sonography | en_US |
| dc.subject | Conservative treatment | en_US |
| dc.title | Effects of micronised purified flavonoid fraction on pain spermiogram and scrotal color doppler parameters in patients with painful varicocele | en_US |
| dc.type | Article | en_US |
