IN-VITRO COMPARISON OF 4 TOCOLYTIC AGENTS, ALONE AND IN COMBINATION

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dc.authorwosidtaskin, omur/C-6864-2016
dc.contributor.authorSAADE, GR
dc.contributor.authorTASKIN, O
dc.contributor.authorBELFORT, MA
dc.contributor.authorERTURAN, B
dc.contributor.authorMOISE, KJ
dc.date.accessioned2024-08-04T20:59:46Z
dc.date.available2024-08-04T20:59:46Z
dc.date.issued1994
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To compare the tocolytic effects of magnesium sulfate, ritodrine, terbutaline, and nifedipine on human myometrial strips. Methods: Myometrial strips were suspended in organ chambers for isotonic measurements and contracted with KCl. Strips from nonpregnant patients were used to obtain concentration-response curves. Myometrial strips from pregnant uteri were then exposed to the molar concentrations causing 50% relaxation in the nonpregnant tissues. Results: In strips from nonpregnant patients, nifedipine was found to be the most potent tocolytic. Using strips from nonlaboring patients, nifedipine caused relaxation similar to ritodrine, and both were more effective than magnesium sulfate or terbutaline. Combinations were more effective than single agents. These agents were found to be equally less effective in myometrial strips from laboring patients. Conclusions: Nifedipine, alone or in combination, relaxes myometrial strips more effectively than the other agents studied. Myometrial strips from laboring patients are more resistant to inhibition, with none of the agents being superior.en_US
dc.identifier.endpage378en_US
dc.identifier.issn0029-7844
dc.identifier.issue3en_US
dc.identifier.pmid8058234en_US
dc.identifier.startpage374en_US
dc.identifier.urihttps://hdl.handle.net/11616/103501
dc.identifier.volume84en_US
dc.identifier.wosWOS:A1994PC43000012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofObstetrics and Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPreterm Labor Tocolysisen_US
dc.subjectMagnesium-Sulfateen_US
dc.subjectHuman Myometriumen_US
dc.subjectRat Uterusen_US
dc.subjectNifedipineen_US
dc.subjectRitodrineen_US
dc.subjectContractilityen_US
dc.subjectTerbutalineen_US
dc.subjectEfficacyen_US
dc.titleIN-VITRO COMPARISON OF 4 TOCOLYTIC AGENTS, ALONE AND IN COMBINATIONen_US
dc.typeArticleen_US

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