Antioxidant Effect of a Dihydropyridine Calcium Antagonist Nitrendipine in Streptozotocin-Induced Diabetes

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dc.authoridIlhan, Nevin/0000-0002-0208-8929
dc.authoridKAYMAZ, MUSTAFA BAHADIR/0000-0002-0033-898X
dc.authorwosidGürsoy, Şule/JPW-8593-2023
dc.authorwosidIlhan, Nevin/J-5761-2017
dc.contributor.authorUnuvar, S.
dc.contributor.authorGursoy, S.
dc.contributor.authorBerk, A.
dc.contributor.authorKaymaz, B.
dc.contributor.authorIlhan, N.
dc.contributor.authorAktay, G.
dc.date.accessioned2024-08-04T20:56:30Z
dc.date.available2024-08-04T20:56:30Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe present study aims to evaluate the effects of a dihydropyridine (DHP) derivative calcium channel antagonist nitrendipine (NIT) on lipid peroxidation (LPO), liver enzyme markers, glucose and lipid profile in rats with streptozotocin (STZ)-induced diabetes. A total of 24 female Sprague Dawley rats were classified into three groups as controls, STZ and STZ+NIT. Fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC) and high-density lipoprotein (HDL) levels, and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity were measured seven weeks after the administration of STZ and NIT. The levels of thiobarbituric acid substance (TBARS), glutathione (GSH) and total thiol content (T-SH), as well as the levels of nitric oxide and metabolites (NO, nitrate, nitrite), were evaluated to assess the level of lipid peroxidation in liver, brain, kidney, heart and eye tissues. STZ significantly increased FBG levels, ALT and AST activity, and TBARS levels (p < 0.001, for all), and significantly reduced the levels of GSH and T-SH (p < 0.05), as well as total NO and nitrate (p < 0.001). STZ triggered LPO in tissues, while simultaneously causing a marked decrease in endogenous antioxidant content. NIT administration protect the kidney (p < 0.05), heart (p < 0.01), brain (p < 0.001) and eye (p < 0.05) tissues from LPO, and also normalized the elevated FBG levels and the activity of ALT and AST (p < 0.001, for all). NIT further stimulated GSH and T-SH production, particularly in the liver, kidney and heart tissues. The results of the present study suggest that NIT shows hypoglycemic activity in STZ-DM rats by increasing insulin sensitivity in the peripheral target tissues.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Department [2011/68]en_US
dc.description.sponsorshipSupported by Inonu University Scientific Research Projects Department, project no. 2011/68.en_US
dc.identifier.doi10.1134/S0022093021010129
dc.identifier.endpage133en_US
dc.identifier.issn0022-0930
dc.identifier.issn1608-3202
dc.identifier.issue1en_US
dc.identifier.startpage126en_US
dc.identifier.urihttps://doi.org/10.1134/S0022093021010129
dc.identifier.urihttps://hdl.handle.net/11616/102375
dc.identifier.volume57en_US
dc.identifier.wosWOS:000618752500012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherPleiades Publishing Incen_US
dc.relation.ispartofJournal of Evolutionary Biochemistry and Physiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdiabetes mellitusen_US
dc.subjectnitrendipineen_US
dc.subjectliver enzymesen_US
dc.subjectoxidative stressen_US
dc.subjectstreptozotocinen_US
dc.titleAntioxidant Effect of a Dihydropyridine Calcium Antagonist Nitrendipine in Streptozotocin-Induced Diabetesen_US
dc.typeArticleen_US

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