Associations of IL-17 and IL-17 receptor polymorphisms with Behcet's disease in Denizli Province of Turkey

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dc.authoridArikan, Sanem/0000-0001-7987-9078
dc.authorwosidArıkan, Sanem/ABI-6170-2020
dc.contributor.authorArikan, Sanem
dc.contributor.authorOztuerk, Onur
dc.contributor.authorDuygulu, Seniz
dc.contributor.authorAtalay, Erol Omer
dc.contributor.authorAtalay, Ayfer
dc.date.accessioned2024-08-04T20:57:12Z
dc.date.available2024-08-04T20:57:12Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAlthough the etiopathogenesis of Behcet's disease is not known, studies conducted in different populations show that it is a multifactorial disease that is thought to develop as a result of the interaction of environmental and genetic factors. IL-17 is thought to induce the neutrophilic inflammation and the tissue damage mediated by immune response in patients. Polymorphisms in the gene region encoding IL-17 and IL-17R molecules may play a critical role in the pathogenesis of the disease and contribute to the elucidation of disease mechanism. We aimed to show the association of IL-17A, IL-17F, and IL-17RC polymorphisms and haplotypes in Behcet's disease patients and its clinical features. We genotyped IL-17A (rs4711998 (A/G), rs8193036 (C/T), rs2275913 (A/G), rs3819025 (A/G), rs8193038 (A/G), rs3804513 (A/T), rs1974226 (C/T), rs3748067 (C/T)); IL-17F (rs763780 (T/C), rs2397084 (T/C)); and IL-17R (IL-17RC) (rs708567 (C/T)) polymorphisms in 88 patients with Behcet's disease and 133 healthy controls using PCR-RFLP-based approach. The results of our study showed that polymorphisms of IL-17A, rs8193036 (C/T), rs3819025 (G/A), rs3804513 (A/T), IL-17F rs2397084 (T/C), and IL-17RC rs708567 (C/T) are associated with the susceptibility to the BD. When the haplotype distributions of all loci of IL-17Aand IL-17A/IL-17F together were examined and in contrast to the data obtained from the controls, the GTGGAACC (27.84%) and GTGGAACCTT (25.57%) have the highest frequencies. In conclusion, the allele and genotype frequency differences of the IL-17A, IL-17F, and IL-17R and haplotype frequencies between Behcet's disease and controls indicate that the genetic structure of Behcet's disease may be different.en_US
dc.description.sponsorshipTUBITAK [SBAG-118S662, SBAG-113S163, SBAG-2388]en_US
dc.description.sponsorshipThis study was supported under the framework of the TUBITAK/ SBAG-118S662, TUBITAK/ SBAG-113S163 and TUBITAK / SBAG-2388.en_US
dc.identifier.doi10.1007/s12026-023-09363-7
dc.identifier.endpage608en_US
dc.identifier.issn0257-277X
dc.identifier.issn1559-0755
dc.identifier.issue4en_US
dc.identifier.pmid36701075en_US
dc.identifier.startpage600en_US
dc.identifier.urihttps://doi.org/10.1007/s12026-023-09363-7
dc.identifier.urihttps://hdl.handle.net/11616/102433
dc.identifier.volume71en_US
dc.identifier.wosWOS:000920839100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofImmunologic Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBehcet's diseaseen_US
dc.subjectIL-17en_US
dc.subjectIL-17Ren_US
dc.subjectHaplotypeen_US
dc.subjectSNPen_US
dc.titleAssociations of IL-17 and IL-17 receptor polymorphisms with Behcet's disease in Denizli Province of Turkeyen_US
dc.typeArticleen_US

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