The Beneficial Effects of Fish Oil Following Cisplatin-Induced Oxidative and Histological Damage in Liver of Rats

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dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authorwosidonat, elif/Y-3938-2019
dc.authorwosidonat, elif/HNQ-6777-2023
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.contributor.authorCiftci, Osman
dc.contributor.authorOnat, Elif
dc.contributor.authorCetin, Asli
dc.date.accessioned2024-08-04T21:01:19Z
dc.date.available2024-08-04T21:01:19Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study investigated the protective effect of fish oil (FO) on cisplatin (CP) toxicity in the rat liver. Twenty-eight rats were divided equally into four groups, with the first being a control group. The second group (CP group) was given 7 mg/kg of CP and the third group (FO group) was given 1 FO softgel/rat/day for 14 days. The rats in the fourth group (CP + FO group) were treated with both CP and FO at the above doses. CP treatment caused significant oxidative damage via an increase in thiobarbituric acid reactive substances (TBARS) and reduced antioxidant defenses through a decrease in the activities of catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH), and glutathione peroxidase (GPx) in rat liver tissue. Also, CP caused histopathological abnormalities, including necrosis, in the liver tissue. However, concurrent FO treatment prevented the negative oxidative and histopathological effects of CP. In conclusion, CP treatment can cause hepatotoxicity in rats, but dietary supplementation with FO can attenuate the oxidative and histological changes caused by CP. Thus, FO may be useful in preventing CP-induced hepatotoxicity in cancer patients.en_US
dc.identifier.endpage1431en_US
dc.identifier.issn1735-0328
dc.identifier.issn1726-6890
dc.identifier.issue4en_US
dc.identifier.pmid29552051en_US
dc.identifier.startpage1424en_US
dc.identifier.urihttps://hdl.handle.net/11616/104288
dc.identifier.volume16en_US
dc.identifier.wosWOS:000414704000013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBrieflanden_US
dc.relation.ispartofIranian Journal of Pharmaceutical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCisplatinen_US
dc.subjectFish oilen_US
dc.subjectHepatotoxicityen_US
dc.subjectOxidative damageen_US
dc.subjectHistological damageen_US
dc.titleThe Beneficial Effects of Fish Oil Following Cisplatin-Induced Oxidative and Histological Damage in Liver of Ratsen_US
dc.typeArticleen_US

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