Efficiency and Side Effects of Isotretinoin Usage in the Treatment of Acne Vulgaris

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dc.contributor.authorCikim, Ahu Ciler
dc.contributor.authorSeyhan, Muammer
dc.date.accessioned2024-08-04T20:58:38Z
dc.date.available2024-08-04T20:58:38Z
dc.date.issued2008
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground and Design: Although satisfying results with isotretinoin therapy were reported in treatment of severe or moderate but resistant acne vulgaris; the data about this treatment modality in Turkey is insufficient. Therefore we aimed to asses the clinical efficiency of isotretinoin treatment in patients with severe or moderate but resistant acne. Material and Method: Ninety four patients were enrolled into the study. The patients were evaluated for clinical symptoms and biochemical parameters; dosage of isotretinoin treatment; response to treatment and adverse events. Patients received 0,5-1 mg/kg/day isotretinoin for 24-32 weeks, with a 120/mg/kg total cumulative dose. The severity of the facial lesions were graded from 0 (no acne) to 12 (severe acne); and corporal lesions (back and chest) from 0 (no acne) to 8 (severe acne). Results: Although three of the patients (3.2%) failed to continue medication; ninety one patients (96.8%) finale the treatment period with complete recovery. The most common clinical side effect was cheilitis which was seen in all the patients and the most important biochemical side effect was the elevation of serum triglyceride concentrations. Conclusion: Isotretinoin can be concluded as a valuable and rather tolerable choice of treatment in patients with severe or moderate but resistant acne vulgaris. (Turkderm 2008; 42: 51-5)en_US
dc.identifier.endpage55en_US
dc.identifier.issn1019-214X
dc.identifier.issn1308-6294
dc.identifier.issue2en_US
dc.identifier.startpage51en_US
dc.identifier.urihttps://hdl.handle.net/11616/103029
dc.identifier.volume42en_US
dc.identifier.wosWOS:000261497700004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherDeri Zuhrevi Hastaliklar Dernegien_US
dc.relation.ispartofTurkderm-Turkish Archives of Dermatology and Venerologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcne vulgarisen_US
dc.subjectisotretinoinen_US
dc.subjectadvers effectsen_US
dc.titleEfficiency and Side Effects of Isotretinoin Usage in the Treatment of Acne Vulgarisen_US
dc.typeArticleen_US

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